Early massive edema caused by severe cerebral contusion results in elevation of intracranial pressure (ICP) and clinical deterioration within 24-72 hours post-trauma. Previous studies indicate that cells in the central area of the contusion undergo shrinkage, disintegration, and homogenization, whereas cellular swelling is predominant in the peripheral area, suggesting that early massive edema ...

Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain injury. The mechanisms for secondary brain injury are not fully understood and successful treatments for traumatic brain injury (TBI) still remain elusive. This study was underta...

The timing of decompressive craniectomy for the treatment of increased intracranial pressure (ICP) after traumatic brain injury (TBI) is a widely discussed clinical issue. Although we showed recently that early decompression is beneficial following experimental TBI, it remains unclear to what degree decompression craniectomy reduces secondary brain damage and if craniectomy is still beneficial ...

Traumatic brain injury (TBI) is an important cause of death with a significant worldwide percentage. In the United States, there are approximately 2.8 million TBIs yearly 250,000 hospitalized patients and 50,000 TBI-related deaths. Every year, one hospitalizations in European Union, resulting more than deaths, most which occur due to road traffic accidents. Needless say, these estimations varie...

Although changes of cerebral blood flow (CBF) in and around traumatic contusions are well documented, the role of CBF for the delayed death of neuronal cells in the traumatic penumbra ultimately resulting in secondary contusion expansion remains unclear. The aim of the current study was therefore to investigate the relationship between changes of CBF and progressive peri-contusional cell death ...

What are the most common causes of spinal cord contusion? Most spinal cord contusion injuries are the result of highimpact motor vehicle accidents. However, athletes can sustain this injury as a result of contact while playing. Fortunately, the number of serious incidents involving spinal cord injury is low. That being said, more orthopedists are beginning to function as the team physician duri...

Recent technological advances have led to improvements in social well being of man’s life in all aspects. This improving and advanced lifestyle is the major cause for some debilitating problems like road traffic accidents. Statistical analysis in literature shows that head and maxillofacial injuries are the most common of these injuries. Recent studies show that fractures of midface are strongl...

We report an extremely rare case of pial arteriovenous fistula (AVF) caused by trauma. A 61-year-old man suffered from brain contusion by a traffic accident. He was neurologically normal on admission. However, his headache gradually worsened, and partial seizures occurred thereafter. He presented with general tonic seizure 7 days after the head injury. Magnetic resonance imaging demonstrated th...

Objective: There are controversies regarding the management of Cerebral Contusion. The study sought to identify parameters influencing surgical outcome individuals suffering from a brain contusion.
 Methods: A quasi-experimental was conducted at Department Neurosurgery, Mayo Hospital Lahore, and 37 patients were included. information on mode/mechanism injury, time presentation, clinical co...