Background: An accurate histopathological assessment and reporting of testicular biopsies require an appropriate tissue fixative. We assessed the histological, histochemical, immunohistochemical quality biopsies, comparing 10% formalin versus Bouin solution as fixatives. Methods: This experimental study utilized 20 adult male albino rats equally divided into five cages for 30 days. By end exper...

Sympathetic nerve fibers arising from the superior cervical ganglia are the main innervation of the rat pineal gland. Since most organs innervated by these ganglia contain nerve growth factor (NGF), the hypothetical existence of NGF in the pineal gland was investigated. The peroxidase anti-peroxidase technique was applied for the immunohistochemical demonstration of NGF using a polyclonal antis...

Detection of the integrin subunit CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia (HCL). Currently, flow cytometric analysis (FC) and frozen section immunohistochemistry (IHC) represent the only available methods of detection. This study is the first to describe the successful use of a CD103 antibody to identify HCL and HCL-variant in paraffin sections of formalin- or ...

Aluminium is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes.The cerebral cortex is a sheet of neural tissue that is outer-most to the cerebrum. This study was conducted in order to evaluate the possible effects that aluminium chloride exposure could have on the histology of cerebral cortex of wistar rats’ offspring.The wistar rats we...

The present review supplies for the first time a comparative approach referring to negative or positive effects of the most important and approved fixation media used in immunohistochemistry (Formalin, Bouin`s solution), that are discussed related to specific impacts caused by the new HOPE fixation technique. Moreover, possible other influences on the effectiveness of the fixatives (specimen co...

BACKGROUND Brains of patients with schizophrenia show both neurodevelopmental and functional deficits that suggest aberrant glutamate neurotransmission. Evidence from both genetic and pharmacological studies suggests that glutamatergic dysfunction, particularly with involvement of NMDARs, plays a critical role in the pathophysiology of schizophrenia. However, how prenatal disturbance of NMDARs ...