The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargemen...

Background: Acute myeloid leukemia (AML) is characterized by the proliferation of myeloid precursors and abnormal differentiation of hematopoietic stem cells, which results in the accumulation of immature cells in the bone marrow (BM). The accumulation of these cells in the bone marrow causes molecular and cellular changes in the microenvironment of the bone marrow. The adiponectin hormone orig...

Gastric cancer is the fifth most commonly diagnosed and fourth leading cause of death worldwide in 2020. usually undergoes lymph node metastasis implantation metastasis, but bone marrow invasion are rare. However, gastric patients with have emergency, so special attention should be paid clinical practice. Herein, we analyzed characteristics an asian patient disseminated intravascular coagulatio...

UNLABELLED Metastatic tumors have been shown to establish permissive microenvironments for metastases via recruitment of bone marrow-derived cells. Here, we show that metastasis-incompetent tumors are also capable of generating such microenvironments. However, in these situations, the otherwise prometastatic Gr1(+) myeloid cells create a metastasis-refractory microenvironment via the induction ...

Skeletal metastases are frequent complications of many cancers, causing bone (fractures, pain, disability) that negatively affect the patient’s quality life. Here, we first discuss burden skeletal in cancer metastasis. We then describe pathophysiology Bone metastasis is a multistage process: long before development clinically detectable metastases, circulating tumor cells settle and enter dorma...

Bone metastasis is a lethal and incurable disease. It is the result of the dissemination of cancer cells to the bone marrow. Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. Because mouse models represent a crucial tool with which to study cancer metast...

Multiple myeloma (MM) is a hematological malignancy resulting from the uncontrolled proliferation of antibody-producing plasma cells in the bone marrow. At diagnosis, independent plasma cell tumors are found throughout the skeleton. The recirculation of mutant plasma cells from the initial lesion and their recolonization of distant marrow sites are thought to occur by a process similar to solid...

Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and strongly correlated with tumor growth, development, metastasis. However, it unclear how the expression FABP5 host affects progression. In this study, using a lung metastasis model mice, we found that FABP5-deficient mice were more susceptible to metastasis, which accompanied by infiltration lower frequency ac...

Bone is a common site of metastasis in human cancer. A major impediment to understanding the pathogenesis of bone metastasis has been the lack of an appropriate animal model. In this paper, we describe an animal model in which B16 melanoma cells injected in the left cardiac ventricle reproducibly colonize specific sites of the skeletal system of mice. Injection of 10(5) cells resulted in melano...