objective(s):immunosuppressive property of mesenchymal stem cells (mscs) has great attraction in regenerative medicine especially when dealing with tissue damage involving immune reactions. the most attractive tissue sources of human mscs used in clinical applications are bone marrow (bm), adipose tissue (at), and wharton's jelly (wj) of human umbilical cord. the current study has compared...

introduction: bone marrow (bm) is a known source of mesenchymal stem cells (mscs) that are used for cell therapy. this study attempts to identify if the wharton’s jelly (wj) is a suitable substitute for bm as a source for mscs. materials and methods: a population of human wj and bm stem cells were isolated and incubated with fluorescein conjugated antibodies for five specific msc markers. cell ...

The bone marrow microenvironment comprises multiple cell niches derived from bone marrow mesenchymal stem cells. However, the molecular mechanism of bone marrow mesenchymal stem cell differentiation is poorly understood. The transcription factor GATA2 is indispensable for hematopoietic stem cell function as well as other hematopoietic lineages, suggesting that it may maintain bone marrow mesenc...

background: bone marrow-derived mesenchymal stem cells (bmmscs) transplantation has been considered as a promising milestone in liver fibrosis treatment. however, low amounts of homing are a major obstacle. we aimed to investigate the role of melatonin pretreatment in bmmsc homing into experimental liver fibrosis. methods: bmmscs were obtained, grown, propagated and preconditioned with 5 µm mel...

objective(s): although many researchers have confirmed induction of germ cells from bone marrow mesenchymal stem cells (bmmscs), there are no reports that confirm spontaneous differentiation of germ cells from bmmscs. in this study, we have evaluated the effect of adult sertoli cell condition medium (sccm) as a mutative factor in the induction of germ cells from bmmscs. materials and methods: b...

objective(s): nowadays much effort is being invested in order to diagnose the mechanisms involved in neural differentiation. by clarifying this, making desired neural cells in vitro and applying them into diverse neurological disorders suffered from neural cell malfunctions could be a feasible choice. thus, the present study assessed the capability of fetal brain extract (fbe) to induce rat bon...

abstractbackground: fetal bovine serum (fbs) is widely used in cell culture laboratories,risk of zoonotic infections and allergic side effects create obstacles for its use inclinical trials. therefore, an alternative supplement with proper inherent growthpromotingactivities is demanded.objective: to find fbs substitute, we tested human umbilical cord blood serum(hucs) for proliferation of human...

Objective(s) The use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (MSC) bone differentiation in culture. In this regard, there is no study considering the effects of Matrigel on mesenchymal stem cell (MSC) in vitro bone differentiation. This was the subject of the present study. Materials and Methods ...