While de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect of de-escalated dosing on a panel of biomarkers and determined their association with incidence of skeletal related events (SREs) in breast cancer...

Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typically indicate bone turnover, but not other features of bone, like bone volume, mineralization, q...

Progressive bone and cartilage destruction in arthritic joints leads to irreversible joint destruction and, subsequently, to functional declines and to work disability. During recent years a lot of interest has been focused on serum biomarkers in the clinic to evaluate the ongoing disease process in the cartilage and bone. New biomarkers such as osteoprotegerin or receptor activator of NF-κB li...

MicroRNAs (miRNAs) are short, endogenous RNA molecules that have essential roles in regulating gene expression. They control numerous physiological and cellular processes, including normal bone organogenesis and homeostasis, by enhancing or inhibiting bone marrow cell growth, differentiation, functional activity and crosstalk of the multiple cell types within the bone. Hence, elucidating miRNA ...

Bone complications occur frequently in Gaucher disease (GD) and reduce the quality of life of these patients. Skeletal involvement is an important indication for treatment to ameliorate symptoms and reduce the risk of irreversible and debilitating disease. Bone biomarkers have been used to assess disease status and the response to therapy in a number of bone disorders. Here, we examine the lite...

Skeletal metastases are frequent complications of many cancers, causing bone (fractures, pain, disability) that negatively affect the patient’s quality life. Here, we first discuss burden skeletal in cancer metastasis. We then describe pathophysiology Bone metastasis is a multistage process: long before development clinically detectable metastases, circulating tumor cells settle and enter dorma...

OBJECTIVE To evaluate the behavior of biomarkers of bone formation and resorption in healthy male Brazilian adolescents according to their biological maturation. METHODS Eighty-seven volunteers were divided into age groups according to bone age (BA): 10-12 years (n = 25), 13-15 years (n = 36), and 16-18 years (n = 26). Weight (kg), height (m), body mass index (kg/m(2)), calcium intake from 3 ...

introduction: acute lymphoblastic leukemia (all) and non-hodgkin's lymphoma (nhl) are the most common childhood and adolescence malignancy respectively.due to the increasing survival of these children, today late side effects of treatments are important. therapies such as corticosteroids, cytotoxic and radiotherapy effect on bone density and put the child at risk of osteoporosis and pathol...