Macrophage migration inhibitory factor (MIF) is a widely expressed cytokine involved in various biological processes. Although MIF's functions in cancer have not been completely elucidated, its expression has usually been correlated with tumour progression and aggressiveness, and it is currently discussed as a new promising target for novel therapies. Recent studies seem to confirm its active r...

Agminated nevus is a cluster group of melanocytic nevi confined to a localized area of the body. There are many pigmented lesions described in the literature as agminated, such as blue nevi, multiple lentigines and Spitz nevi, but only a few cases of congenital agminated melanocytic nevi have been described. We report a case of a male child who presented with congenital agminated nevi, emphasiz...

Blue nevi are uncommon, asymptomatic lesions of the uterine cervix. These lesions are not often detected clinically or on colposcopy. Careful histopathological examination is required. The nevus cells are said to originate from the immature melanoblasts of the neural crest. These lesions need to be differentiated from malignant melanoma and melanosis of the cervix. We present here a case report...

BACKGROUND Currently, there is disagreement as to whether speckled lentiginous nevi (nevi spili) are congenital or acquired pigmented lesions. Part of this controversy is related to the natural history of these lesions that often present at birth as hyperpigmented patches and then take several years to reach their more readily recognized spotted form. Arguments in favor of speckled lentiginous ...

BACKGROUND Melanomas and melanocytic nevi that change over time display different change patterns, correlated with histopathological features. METHODS We performed a retrospective analysis of the dermoscopic images corresponding to 86 lesions excised due to the changes occurred during the follow-up period in patients at high risk for melanoma, and we drew a comparison between the changes occu...

Pigmented lesions of the cervix are a rarity. Blue nevus occurs as an incidental finding in cervix in hysterectomy specimens from middle aged women. This condition is more appropriately called ‘Focal Stromal Melanocytosis” as the findings are more analogous to dermal melanocytosis rather than to cutaneous blue nevi. There are only a couple of reports of cervical blue nevi in the Indian literatu...

Nevi are pigmented lesions of bluish-black colour that may occasionally occur in the oral cavity. Out several melanocytic nevi (OMN), blue significant as some variants diagnostically challenging due to histopathological overlap with malignant melanoma. The aim present report was clinico-pathologic characteristics 8 new cases intraoral common and 22 OMN. A literature review-based comparison clin...

OBJECTIVE To evaluate with immunohistochemical methods 5 atypical melanocytic conjunctival lesions. METHODS This was a retrospective clinicoimmunopathologic study. Routine histochemical staining was performed with multiparametric immunohistochemical analysis with monoclonal antibodies immunoreacted on paraffin sections to identify the following cell antigens: S-100, MART-1, HMB-45, CD45, CD68...