Blood coagulation could be recognized as intrinsic inflammation. The coagulant mediators (FVIIa, FXa, thrombin (FIIa), FXIIa) and fibrin(ogen) activate cellular signaling, eliciting the production of cytokines, chemokines, growth factors, and other proinflammatory mediators. Hypercoagulability with elevated coagulant mediators would certainly trigger hyper-inflammatory state not to mention abou...

Affinity chromatography of human cryosupernatants on anti-human factor VIII-Sepharose yielded a plasma devoid of detectable factor VIIIC, VIIIR:Ag, and VIIIR:WF activities. This plasma was indistinguishable from severe congenital hemophilic plasma when used as substrate in factor VIII coagulant assays.

A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3-5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays.

We evaluated systemic alterations to the blood coagulation system that occur during a coronary thrombotic event. Peripheral blood coagulation in patients with acute coronary thrombosis was compared with that in people with stable coronary artery disease (CAD). Blood coagulation and platelet activation at the microvascular injury site were assessed using immunochemistry in 28 nonanticoagulated p...

The ability of a commercial tannin-based coagulant on the decolorization simulated textile effluent containing reactive dye was studied in batch mode. For comparison, two conventional chemical coagulants (aluminum sulfate and Rifloc 6548-organic coagulant) were also tested. Preliminary assays suggested higher performance Tanfloc SG over metal salt. Optimization conducted for SG, indicated maxim...

We evaluated systemic alterations to the blood coagulation system that occur during a coronary thrombotic event. Peripheral blood coagulation in patients with acute coronary thrombosis was compared with that in people with stable coronary artery disease (CAD). Blood coagulation and platelet activation at the microvascular injury site were assessed using immunochemistry in 28 non-anticoagulated ...

1. Human placenta microsomes active in blood coagulation have been prepared by a combination of differential centrifugation, density gradient centrifugation, and extraction with butanol-benzene mixtures. Human brain particles have been prepared from acetone-dried brain by extraction with sodium chloride solutions, differential centrifugation, and extraction with butanol-benzene mixtures. 2. Pla...

THIS book is a report of the symposium on thrombosis and related problems arranged by Prof. P. A. Owren, Prof. R. B. Hunter, and Dr. W. Walker in the University of St. Andrews, Dundee, Scotland. A team of international experts were gathered together for this symposium and the proceedings were conducted in English. The book contains all the papers which were given together with the discussions w...

Purification of Hageman factor (HF, factor XII) from human plasma is a tedious procedure and the product is not always in the precursor form. Hojima has described a protein derived from corn kernels that inhibits the enzymatic properties of HF. This inhibitor binds to the precursor form of HF. Rapid purification of HF was achieved by using as the major purification step adsorption of this clott...