Allergen-specific immunotherapy (AIT) is the only treatment of IgE-mediated allergies so far that has a sustained effect on clinical symptoms and can modify the course of the disease. It is an allergen-specific treatment and therefore requires the correct identification of the disease-causing allergens. Furthermore, AIT is a time-consuming treatment for which the efficacy is dependent on severa...

Therapeutic antibodies that block PD-1-mediated inhibition of T cells have revolutionized cancer therapy. Murine models are an essential tool for testing the efficacy PD-1 blockers alone or in combination with other treatments. Depending on isotype antibody and host species, blocking can also exert cytotoxic activity towards expressing target molecule. In current issue European Journal Immunolo...

It was found that exposure of hemagglutinating sera to pressures of the order of 3,000 to 4,000 atmospheres destroyed their agglutinating power, but did not convert them to inhibiting ("blocking") antibodies. Higher pressures (4,500 to 5,500 atmospheres) were required to destroy inhibiting anti-Rh(0) antibodies in a "blocking" serum. This conforms with ideas already held that the "blocking" ant...

‘SINCE the discovery by Paul and BunnelP in 1932. of the presence of heterophile . antibodies in the sera of patients with infectious mononucleosis, there has been a great deal of investigation into the nature and production of anti-sheep red cell aggulutinins.’ With the advent of the Rh factor and the subsequent discovery of blocking3 (incomplete,4 or hyperimmune5) antibody new avenues of appr...

blocking antibodies are valuable tools for inhibiting the specific receptor- ligand interactions. the interaction of co-stimulatory molecules on the antigen presenting cells with their ligands on t cells is an essential step for t cell activation. in the present study, the effect of blocking antibody against cd40 on its t cell stimulatory potential is investigated. the dcs (dendritic cells) wer...

Despite the various therapies available, the use of monoclonal antibodies is a highly specific approach that has only recently been of interest to researchers. The properties of antibodies have led to their use in the treatment of various diseases, including cancer, Alzheimer's disease, diabetes and multiple sclerosis (MS). MS, a chronic inflammatory disease, occurs commonly in young adults. Th...