The ability of DNA to adopt non-canonical structures can affect transcription and has broad implications for genome functioning. We have recently reported that guanine-rich (G-rich) homopurine-homopyrimidine sequences cause significant blockage of transcription in vitro in a strictly orientation-dependent manner: when the G-rich strand serves as the non-template strand [Belotserkovskii et al. (...

BACKGROUND Hydrocephalus is the abnormal accumulation of cerebrospinal fluid within the ventricles and subarachnoid spaces, resulting in increased intracranial pressure. The treatment of choice is placement of ventriculoperitoneal shunt. Ventriculoperitoneal shunt blockage is not an uncommon complication. Objective of the study was to find out the frequency, causes and site of ventriculoperiton...

The ability to accurately evaluate hydrokinetic turbine concepts at small-scale in experimental facilities is important for the development of new devices. Problems introduced by working at lab-scale include operation in a transitional Reynolds number regime and cross-sectional blockage. These factors are shown to influence performance characteristics of a helical cross-flow turbine tested over...

four patients were studied for intercostals nerve blockade in cholecystectomy. all of the patients were poor risks (class 4) and received premedication before the procedure. intercostals nerve blockade (icnb) of the 7th and 10th thoracic nerves on the right side was performed with lidocaine 1% plus adrenaline 5 ml. at each segment, t7-t10 (a total dose of 20 ml). ventilation was controlled usin...

We investigate the totally asymmetric exclusion process on Z, with the jump rate at site i given by ri = 1 for i 6= 0, r0 = r. It is easy to see that the maximal stationary current j(r) is nondecreasing in r and that j(r) = 1/4 for r ≥ 1; it is a long outstanding problem to determine whether or not the critical value rc of r such that j(r) = 1/4 for r > rc is strictly less than 1. Here we prese...

Whether a state of nasal hyperresponsiveness influences antigen-induced biphasic nasal blockage and sneezing were examined using a guinea pig model of allergic rhinitis. Sensitized animals were challenged with an antigen, Japanese cedar pollen, once every week. Before the 13th challenge, the animals were randomly divided into 2 groups, and then the 13th challenge was performed (Groups A-0 and B...

We analyze the performance of a free-space optical (FSO) link affected by atmospheric turbulence and line-of-sight (LOS) blockage. For this purpose, the atmospheric turbulence induced fading is modeled by the ℳ distribution, which includes the Gamma-Gamma distribution as special case. We exploit the fact that the physical interpretation of the ℳ distribution allows to split the optical energy t...