We studied the kinetics of the use-dependent block of the Na+ current (INa) by disopyramide and lidocaine. INa was recorded from isolated guinea pig ventricular myocytes by using the whole-cell patch-clamp technique. The use-dependent block of INa by disopyramide with 20- and 200-msec depolarizing pulses developed in two exponential functions. The degree of the use-dependent block and the ampli...

In this paper, the properties of the floor function has been used to find a function which is one on the interval [0, 1) and is zero elsewhere. The suitable dilation and translation parameters lead us to get similar function corresponding to the interval [a,b)[a,b). These functions and their combinations enable us to represent the stepwise functions as a function of floor function. We have appl...

recently, the block-pulse functions (bpfs) are used in solving electromagnetic scattering problem, which are modeled as linear fredholm integral equations (fies) of the second kind. but the theoretical aspect of this method has not fully investigated yet. in this article, in addition to presenting a new approach for solving fie of the second kind, the theory of both methods is investigated as a...

In this paper, an effective numerical method is introduced for the treatment of nonlinear two-dimensional Volterra-Fredholm integro-differential equations. Here, we use the so-called two-dimensional block-pulse functions.First, the two-dimensional block-pulse operational matrix of integration and differentiation has been presented. Then, by using this matrices, the nonlinear two-dimensional Vol...

In this paper, we use a combination of Legendre and Block-Pulse functionson the interval [0; 1] to solve the nonlinear integral equation of the second kind.The nonlinear part of the integral equation is approximated by Hybrid Legen-dre Block-Pulse functions, and the nonlinear integral equation is reduced to asystem of nonlinear equations. We give some numerical examples. To showapplicability of...

in this paper, an effective numerical method is introduced for the treatment of nonlinear two-dimensional volterra-fredholm integro-differential equations. here, we use the so-called two-dimensional block-pulse functions.first, the two-dimensional block-pulse operational matrix of integration and differentiation has been presented. then, by using this matrices, the nonlinear two-dimensional vol...

properties of the hybrid of block-pulse functions and lagrange polynomials based on the legendre-gauss-type points are investigated and utilized to define the composite interpolation operator as an extension of the well-known legendre interpolation operator. the uniqueness and interpolating properties are discussed and the corresponding differentiation matrix is also introduced. the applicabili...

In this paper, an effective numerical method is introduced for the treatment of nonlinear two-dimensional Volterra-Fredholm integro-differential equations. Here, we use the so-called two-dimensional block-pulse functions.First, the two-dimensional block-pulse operational matrix of integration and differentiation has been presented. Then, by using this matrices, the nonlinear two-dimensional Vol...

in this paper, we use a combination of legendre and block-pulse functionson the interval [0; 1] to solve the nonlinear integral equation of the second kind.the nonlinear part of the integral equation is approximated by hybrid legen-dre block-pulse functions, and the nonlinear integral equation is reduced to asystem of nonlinear equations. we give some numerical examples. to showapplicability of...

In this work, we will compare two approximation method based on hybrid Legendre andBlock-Pulse functions and a computational method for solving nonlinear Fredholm-Volterraintegral equations of the second kind which is based on replacement of the unknown functionby truncated series of well known Block-Pulse functions (BPfs) expansion