BACKGROUND Automated blood cell analyzers often read leukemic blasts as normal cells. In this study, we evaluated the 5-part differential patterns of blasts using automated analyzers to determine if they can differentiate among blast types. METHODS Blood samples containing 10% or more blasts were collected from patients with acute leukemia (N=175). The 5-part differential count was conducted ...

CMAJ • FEBRUARY 9, 2010 • 182(2) © 2010 Canadian Medical Association or its licensors 171 Apreviously healthy four-year-old girl presented with a rash of sudden onset consisting of erythematous macules on both cheeks (Figure 1) that were neither itchy nor tender and did not blanch. Over the next week, the rash spread from her cheeks to her arms, back, thighs and buttocks, and became papular and...

conclusions when evaluating flank pain in patients, it is important to remember that cbc parameters may support urinary stone disease, and considering cbc results may be useful in the diagnosis of urinary stone disease. patients and methods this study was a retrospective observational study of 3,099 patients who were admitted to the urology outpatient clinic or diagnosed with urinary stone dise...

P.M., a seventy year old Polish-born male clerk, was referred to the Hematology Clinic in September 1963. Examination in another medical service in 1961 had revealed moderate hepatosplenomegaly, a platelet count of 900,000 per cu.mm. with normal red and white blood cell counts, and megakaryocytic hyperplasia in bone marrow with excessive platelet production and hyperplasia of the white cell ser...

Diagnostic bone marrow smears from 132 patients with acute lymphoblastic leukaemia, (ALL) were stained simultaneously by the periodic acid-Schiff (PAS) reaction, and the blast cell positivity was assessed quantitatively. The patients fell naturally into two unequal groups: those with more than 20% PAS-positive blast cells (44 patients) and those with less (88 patients). There was no relation be...

conclusions according to the results of this study, effect of biochemical interfering factors on test results of impedance cell counter must be considered in clinical laboratories. results comparison between case and control groups revealed that uremia caused significant increase in mcv and rdw levels (p < 0.05) and had no effect on mch level (p > 0.05). both hyperglycemia and hyperlipemia caus...

BACKGROUND Hematology analyzers may ineffectively recognize abnormal cells, and manual differential counts may be imprecise for leukopenic samples. We evaluated the efficacy of the Hematoflow method for determining the leukocyte differential in leukopenic samples and compared this method with the manual differential method. METHODS We selected 249 blood samples from 167 patients with leukopen...

Case Report Baby WM was the first live born child of the family. Her 18-year-old mother had swollen ankles, lower abdominal pain and reduced fetal movements at 31st weeks of gestation. Ultrasound scan showed fetal car-diomegaly and early hydropic changes including hepatomegaly and swollen placenta. No maternal-fetal haemorrhage could be demonstrated by Kleihauer test. A baby girl was delivered ...

A 21-yr-old man presented with inguinal lymphadenopathy and splenomegaly. The peripheral blood showed a high blast cell count. The morphological and immunologic features of the blast cells were consistent with the diagnosis of common acute lymphoblastic leukemia (ALL) with 15% pre-B-cells. Banded karyotype analysis of the blood and the marrow cells, using the technique of methotrexate synchroni...

Early response to therapy, typically assessed by bone marrow status, is predictive of outcome in childhood acute lymphoblastic leukemia (ALL). Less is known about the significance of early clearance of blast cells in peripheral blood. We reviewed medical records of all patients with ALL enrolled on St Jude Total Therapy Study XI (February 1984 to September 1988) to determine the presence of bla...