Background: Carbapenem-resistant Acinetobacter baumannii strains are one of the most severe factors in hospital infection worldwide, which beta-lactamase enzyme is main resistance mechanisms. Objectives: This study aimed to evaluate presence carbapenem-resistant genes and determine antibiotic patterns clinical isolates A. from patients hospitalized Shahid Kamyab Hospital, Mashhad, Iran. Methods...

The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a major public health concern worldwide and a new challenge in the treatment of infectious diseases. The molecular characteristics of Enterobacter cloacae in Ningxia China are unknown. In this study, we reported 10 carbapenem-resistant E. cloacae isolates from the General Hospital of Ningxia Medical University, the larges...

The study aimed to investigate the occurrence of carbapenem resistant E. coli and P. aeruginosa in apparently healthy, captive blackbucks leopards India. Faecal samples (n = 7) were processed isolate (CRE) (CRP). Forty (leopards n 26; blackbuck 14) two (blackbuck 2) isolated from faecal 14). Eleven isolates recovered, which 10 CRE one was CRP. minimum inhibitory concentration (MIC) determined f...

Introduction and Aim: Carbapenem Resistant Enterobacteriaceae (CRE) have emerged at an alarming rate. Multi locus sequence typing (MLST) is important parameter for identifying drug resistant organisms. The present study was carried out elucidating the mechanisms of CRE MLSTs associated with CRE. Materials Methods: (n=14) were obtained from various clinical samples subjected to Rapidec Carba NP ...

In this study, phenotypic and genotypic methods were used to detect metallo-β-lactamases, cephalosporinases and oxacillinases and to assess genetic diversity among 64 multiresistant Acinetobacter baumannii strains recovered from blood cultures in five different hospitals in Brazil from December 2008 to June 2009. High rates of resistance to imipenem (93.75%) and polymyxin B (39.06%) were observ...

Over the last decade, nosocomial infections with Acinetobacter baumannii have been described with an increasing trend toward multidrug resistance, mostly in intensive care units (ICUs) (6, 9, 11). The main mechanism of resistance to carbapenems in A. baumannii is the production of acquired OXA-type carbapenemases, which have been frequently identified worldwide and are clustered in three major ...

BACKGROUND & OBJECTIVES Pseudomonas aeruginosa possessing chromosomally inducible blaPDCalong with other intrinsic mechanism causes infection with high mortality rate. It is difficult to detect inducible AmpC enzymes in this organism and is usually overlooked by routine testing that may lead to therapeutic failure. Therefore, three different inducers were evaluated in the present study to asses...

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion and agar-based antimicrobial susceptibility testing were initially performed to determine the in...

conclusions isaba1 has become an important factor in a. baumannii’s resistance to cefotaxime. results isaba1 located upstream of blaampc was found in 24 (48%) of the a. baumannii isolates. in all of the studied isolates that had isampc, the mic for cefotaxime was 64 - 256 μg/ml. based on the rep-pcr patterns among the resistant isolates, the highest number of isampc positive isolates belonged t...