نتایج جستجو برای: bitter melon

تعداد نتایج: 8075  

2014
Jimmy T. Efird Yuk Ming Choi Stephen W. Davies Sanjay Mehra Ethan J. Anderson Lalage A. Katunga

Bitter Melon (Momordica charantia) is a widely used traditional remedy for hyperglycemia. While the medicinal properties of this plant have been studied extensively using in vitro and animal models, the clinical efficacy and safety in humans is largely unknown. This review discusses the benefits and limitations of bitter melon supplementation in the context of epidemic levels of insulin resista...

2014
Heping Cao Kandan Sethumadhavan Casey C. Grimm Abul H. J. Ullah

Momordica charantia is often called bitter melon, bitter gourd or bitter squash because its fruit has a bitter taste. The fruit has been widely used as vegetable and herbal medicine. Alpha-eleostearic acid is the major fatty acid in the seeds, but little is known about its biosynthesis. As an initial step towards understanding the biochemical mechanism of fatty acid accumulation in bitter melon...

Journal: :The Journal of nutrition 2005
Pratibha V Nerurkar Laurel Pearson Jimmy T Efird Khosrow Adeli Andre G Theriault Vivek R Nerurkar

Momordica charantia or bitter melon is traditionally used as an antidiabetic agent in Asia, Africa, and South America. Recent studies indicate that bitter melon can also lower plasma lipids and VLDL in diabetic animal models as well as animals fed a high-fat diet, suggesting an effect on lipoprotein metabolism. The aim of this study was to delineate the cellular and molecular mechanisms involve...

2011
Nilda Z. A. Jiménez Helena G. Montano

Part of the Master Thesis of the first author. Universidade Federal Rural do Rio de Janeiro. Seropédica RJ. 2008. ABSTRACT Phytoplasmas can cause yield losses in numerous crops worldwide. In Brazil, phytoplasmal diseases have been reported in plant species, distributed among 29 botanical families. Chayote witches’-broom (ChWB) is reported as one of the diseases of economic importance, associate...

2015
Inayat U Rahman Rooh Ullah Khan Khalil Ur Rahman Mohammad Bashir

OBJECTIVE Since antiquity bitter melon has been in use for treating diabetes but clinical trials show conflicting results about its usefulness. The present study aims to asses and compare the hypoglycemic and antiatherogenic effects as well as the safety of two different doses of bitter melon with glibenclamide. METHODS A total of 95 participants were randomized into 3 groups; group I and gro...

2016
Mingo M. H. Yung Fiona A. Ross D. Grahame Hardie Thomas H. Y. Leung Jinbiao Zhan Hextan Y. S. Ngan David W. Chan

UNLABELLED Objective Acquired chemoresistance is a major obstacle in the clinical management of ovarian cancer. Therefore, searching for alternative therapeutic modalities is urgently needed. Bitter melon (Momordica charantia) is a traditional dietary fruit, but its extract also shows potential medicinal values in human diabetes and cancers. Here, we sought to investigate the extract of bitter ...

2006
Catherine Jilka Beth Strifler G. William Fortner Esther F. Hays Dolores J. Takemoto

The in vivo antitumor activity of a crude extract from the bitter melon (Momordica charantia) was determined. The extract inhib ited tumor formation in CBA/H mice which had been given i.p. injections of 1.0 x 105 CBA/DI tumor cells (77% of the untreated mice with tumors versus 33% of the treated mice with tumors after 6 weeks). The extract also inhibited tumor formation in DBA/2 mice which had ...

Journal: :Cancer research 1983
C Jilka B Strifler G W Fortner E F Hays D J Takemoto

The in vivo antitumor activity of a crude extract from the bitter melon (Momordica charantia) was determined. The extract inhibited tumor formation in CBA/H mice which had been given i.p. injections of 1.0 X 10(5) CBA/Dl tumor cells (77% of the untreated mice with tumors versus 33% of the treated mice with tumors after 6 weeks). The extract also inhibited tumor formation in DBA/2 mice which had...

Journal: :Cytokine 2009
Takehiro Ono Tomoe Tsuji Miho Sakai Chizuko Yukizaki Hisatoshi Ino Isao Akagi Kaori Hiramatsu Yohsuke Matsumoto Yoshihiro Sugiura Hirofumi Uto Hirohito Tsubouchi Eiichi Gohda

Hepatocyte growth factor (HGF) is useful as a potential therapeutic agent for hepatic and renal fibrosis and cardiovascular diseases through inducing proliferation of epithelial and endothelial cells. HGF inducers may also be useful as therapeutic agents for these diseases. However, there have been no reports on induction of HGF production by plant extracts or juices. An extract of bitter melon...

2013
Deep Kwatra Dharmalingam Subramaniam Prabhu Ramamoorthy David Standing Elizabeth Moran Ravichandiran Velayutham Ashim Mitra Shahid Umar Shrikant Anant

Bitter melon fruit is recommended in ancient Indian and Chinese medicine for prevention/treatment of diabetes. However its effects on cancer progression are not well understood. Here, we have determined the efficacy of methanolic extracts of bitter melon on colon cancer stem and progenitor cells. Both, whole fruit (BMW) and skin (BMSk) extracts showed significant inhibition of cell proliferatio...

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