A significant overlap between childhood mood disorders and many aspects of attention deficit hyperactivity disorder (ADHD) has been established. High rates of co-occurrence, familial aggregation, and more severe clinical manifestations of the illnesses when they are comorbid suggest that common genetic and environmental factors may contribute to the development of both disorders. Research on th...

Given its prevalence and impact on public health, the comorbidity of bipolar and substance use disorders is one of the most relevant of dual diagnoses. The objective was to evaluate the characteristics of patients from community mental health and substance abuse centres in Madrid. The sample consisted of 837 outpatients from mental health and substance abuse centres. We used the Mini Internatio...

BACKGROUND Bipolar disorder is a common psychiatric mood disorder that is defined by recurrent episodes of abnormally elevated mood and depression. Progressive structural brain changes in individuals with bipolar disorder have been suggested to be associated with defects in the secretion of neurotrophic factors. We sought to assess how the regulated secretory pathway in the brain is affected in...

BACKGROUND Persistent impairments in neurocognitive function have been described in bipolar disorder. AIMS To compare the cognitive performance of patients with bipolar II disorder with that of patients with bipolar I disorder and a healthy control group. METHOD The study included 71 euthymic patients with bipolar disorder (38 bipolar I, 33 bipolar II), who were compared on clinical and neu...

About 20-30 years ago the central pillar of psychiatry was schizophrenia. Today ́s interest has turned to a new paradigm bipolar disorder. Knowledge, skills and experiences in treatment of bipolar affective disorder are being enriched with new insights concerning molecular basis of disorder and psychosocial factors importance in its genesis and development, fostering presonalized psyhopharmacoth...

AIM To assess the level of caregiving burden and psychological distress among spouses of bipolar disorder - BD (type I and II) patients. METHODS 77 subjects (41 women and 36 men) were enrolled in the study - 44 spouses of bipolar I (BD I) patients and 33 spouses of bipolar II (BD II). The whole group was divided into 4 subgroups: (I) the wives of BD I patients: n=27, (II) the husbands of BD I...

objective: with regard to the abundance of mood disorders among the artists and, life and death of hedayat, number and time of creation of his works, this hypothesis that hedayat suffered from a bipolar mood disorder (type ii, or bipolar spectrum) is studied in the descriptive psychiatry framework. methods: his biographies, medical records, letters exchanged between him and his friends and rela...

Outcome in bipolar patients is affected by comorbidity. Comorbid personality disorders are frequent and may complicate the course of bipolar illness. This pilot study examined a series of 40 euthymic bipolar patients (DSM-IV criteria) (bipolar I disorder 31, bipolar II disorder 9) to assess the effect of clinical variables and the influence of comorbid personality on the clinical course of bipo...