1Max Delbrück Center for Molecular Medicine, Berlin, Germany 2Laboratório de Reatividade Cardiovascular (LRC), Núcleo de Sı́ndromeMetabólica, Universidade Federal de Alagoas, Maceió, Brazil 3National Institute of Science and Technology in Nano-Biopharmaceutics (N-BIOFAR), Belo Horizonte, Brazil 4Departamento de Fisiologia e Farmacologia, Centro de Biociências (CB), Universidade Federal de Pernam...

a healthcare system has been the most important priority for all governments worldwide. biotechnology products have affected the promotion of health care over the last thirty years. during the last several decades, iran has achieved significant success in extending healthcare to the rural areas and in reducing the rates of infant mortality and increasing population growth. biomedical technology...

Ulrike Günther, Marcus Hartmann, Siegfried Wartewig, Reinhard Neubert Martin-Luther-Universität Halle-Wittenberg, 1 Institute of Pharmaceutics and Biopharmaceutics, 2 Institute of Applied Dermatopharmacy, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany, E-Mail: [email protected]

The Biopharmaceutics Classification System (BCS) was developed for prediction of in vivo pharmacokinetic performance of drug products from measurements of permeability and solubility. If the permeability criteria changed with metabolism criteria than it may be useful in predicting overall drug disposition, including routes of drug elimination and the effects of efflux and absorptive transporter...

Microencapsulation is a technology that has shown significant promise in biotherapeutics, and other applications. It has been proven useful in the immobilization of drugs, live mammalian and bacterial cells and other cells, and other biopharmaceutics molecules, as it can provide material structuration, protection of the enclosed product, and controlled release of the encapsulated contents, all ...

The intestinal transport of lamivudine, a nucleotide reverse transcriptase inhibitor, was investigated using the single pass intestinal perfusion technique in male Wistar rats. Single pass intestinal perfusion was performed in small intestine at a flow rate of 0.20 ml/min. Lamivudine exhibits a high intestinal permeability over the length of the small intestine indicative of compounds that are ...

Specific biopharmaceutics classification investigation and study on phamacokinetic profile of a novel drug candidate (2-methylcarbamoyl-4-{4-[3- (trifluoromethyl) benzamido] phenoxy} pyridinium 4-methylbenzenesulfonate monohydrate, NCE) were carried out. Equilibrium solubility and intrinsic dissolution rate (IDR) of NCE were estimated in different phosphate buffers. Effective intestinal permeab...