1. Abstract 2. Introduction 3. Materials and Methods 3.1. Synthesis of polymer substrates containing biomimetic oligopeptides 3.2. In vitro macrophage and FBGC assays 3.3. In vivo cage implantation study 3.4. Statistical analysis 4. Results and Discussions 4.1. In vitro macrophage adhesion and FBGC formation 4.2. In vivo macrophage adhesion and FBGC formation 4.3. Probing the intracellular sign...

The biomimetic synthesis and full structural elucidation of rubicordifolin, a cytotoxic natural product isolated from Rubia cordifolia, is described.

As more methodologies for generating and manipulating biomimetic cellular systems are developed, opportunities arise for combining different methods to create more complex synthetic biological constructs. This necessitates an increasing need for tools to selectively trigger individual methodologies. Here we demonstrate ruthenium tris-bipyridine mediated photoredox triggering of the copper catal...

Studies towards the biomimetic synthesis of cardinalin 3 are described. Despite the successful enantioselective synthesis of the monomeric pyranonaphthoquinone ventiloquinone L, it subsequently failed to undergo a proposed biomimetic homodimerisation to cardinalin 3 using a range of oxidants. However, treatment of a related naphthopyran with cerium ammonium nitrate (CAN) facilitated a tandem bi...

The first chemical total synthesis of the highly oxygenated polyketide enterocin has been accomplished. key step was a late-stage biomimetic reaction cascade involving two intramolecular aldol reactions in which each proceeded 52 % yield (averaged) and established four seven stereogenic centers. pivotal precursor for assembled from three readily available building blocks. A chiral dithioacetal ...