The multivalent character of dendrimers has positioned these well-defined, highly branched macromolecules at the forefront in the development of new contrast agents for biomedical magnetic resonance imaging (MRI). By modifying the periphery of the dendrimer with gadolinium(III) chelates, the relaxivity of the resulting MRI contrast agent is increased considerably, compared to low molecular weig...

Holograms can shape wavefronts to produce arbitrary acoustic images. In this work, we experimentally demonstrate how holograms controlled thermal patterns in absorbing media at ultrasonic frequencies. Magnetic resonance imaging (MRI)-compatible holographic ultrasound lenses were designed by time-reversal methods and manufactured using 3D-printing. Several measured MRI thermometry a thermographi...

This chapter gives an introduction to the principles of diffusion magnetic resonance imaging (MRI) with emphasis on the computational aspects. It introduces the philosophies underlying the technique and shows how to sensitize MRI measurements to the motion of particles within a sample material. The main body of the chapter is a technical review of diffusion MRI reconstruction algorithms, which ...

Abstract Transcranial Doppler (TCD) blood flow velocity has been extensively used in biomedical research as it provides a cost-effective and relatively simple approach to assess changes cerebral dynamics track cerebrovascular health status. In this article we introduce new TCD-based timing index, TITCD, an indicator of vascular stiffening health. We investigate the correlati...

Biomedical signals are observations of physiological activities of organisms, ranging from gene and protein sequences, to neural and cardiac rhythms, to tissue and organ images. Biomedical signal processing aims at extracting significant information from biomedical signals. With the aid of biomedical signal processing, biologists can discover new biology and physicians can monitor distinct illn...

S. Plein, S. Radjenovic, S. Ryf, S. Kozerke, P. Boesiger, and J. Schwitter Cardiac MRI group, University of Leeds, Leeds, W. Yorkshire, United Kingdom, Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, Medical Physics, University of Leeds, United Kingdom, Institute for Biomedical Engineering, University and ETH Zurich, Switzerland, Cardiology department, Univ...

Positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used in vivo imaging technologies with both clinical and biomedical research applications. The strengths of MRI include high-resolution, high-contrast morphologic imaging of soft tissues; the ability to image physiologic parameters such as diffusion and changes in oxygenation level resulting from neuronal stimula...

A. Fatemi, E. M. Haacke, and M. D. Noseworthy Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada, Radiology, Wayne State University, Detroit, Michigan, United States, The MRI Institute for Biomedical Research, Detroit, Michigan, United States, Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario...

Medical physicists have made many important contributions to biomedical research. In medical imaging physics, important contributions include the development of advanced imaging methods in such areas as functional MRI, proton and phosphorus spectroscopy, diffusion tensor imaging, optical imaging, digital radiography, and near-infrared spectroscopy. The radiation imaging techniques have received...

Mary MCLEAN1, Robert SIMISTER2, Friedrich WOERMANN3, Lawrence WALD4, Stephen WILLIAMS5, John DUNCAN6 1National Society for Epilepsy, MRI Unit, Gerrards Cross, BUCKS UK; 2National Society for Epilepsy, MRI Unit, Gerrard's Cross, BUCKS UK; 3The National Society for Epilepsy, MRI Unit, Gerrards Cross, Bucks UK; 4Harvard University, MGH-NMR Center, Building 149, 13th Street, Charlestown, MA ; 5Univ...