rodlet cells are frequently found in teleost fishes and although their role in organisms is not completely understood. the occurrence of these cells are related to stress and may undergo changes in contaminated environments, thereby allowing their use as biomarkers. this hypothesis is tested in the present study. thirty specimens of oreochromis niloticus were divided into three groups, two grou...

introduction: serum c-reactive protein (crp) is believed to be increased in metastatic urothelial cancer of the bladder. however, the changes depend on the stage and grade of the upper tract urothelial carcinoma (utuc). this study aimed to compare low-range and high-range serum crp and haptoglobin in new cases of utuc. materials and methods: blood was collected from newly diagnosed patients wit...

background: serologic screening of gastric cancer (gc) by serum pepsinogens (spg) levels and helicobacter pylori (hp) sero-status, though highly informative, has provided heterogeneous results. here, we have evaluated the modifying effects of demographic factors on the risk impact of hp sero-status/spg levels in gastric cancer, with particular emphasis on age. methods: a cross-sectional study w...

micrornas are highly conserved small non-coding regulatory rnas that involve in post transcriptional regulating of gene expression during different cellular mechanisms. aberration of mir-218 expression during tumorigenesis of different solid tumors has been reported by numerous studies. in current systematic review article, by using the terms “mir-218” and “cancer” we first searched for english...

according to the definition by the national institutes of health of usa, a biological marker (biomarker) is a characteristic that is objectively measured and evaluated, as an indicator of normal biological processes, pathogenic processes or pharmacological responses, to a therapeutic agent. several studies have reported that a decreased regulating gene expression of biotinidase (btd) is associa...

this study investigated the cytochemical responses in hediste diversicolor exposed to the environmental concentrations of cadmium (1µm cd), copper (1µm cu) and to their equimolar mixture for 48h. lysosomal membrane stability (lms), neutral lipids (nl) level, lipofuscin (lf) content and ca2+-atpase activity were determined as early subcellular biomarkers of toxicity. the biomarker battery pointe...

conclusions the expression of recombinant calprotectin, as an effective protein, can help in diagnosis or treatment of inflammatory and cancer processes in the future. furthermore, ca2+ induced a partial change in secondary and tertiary structure of calprotectin subunits and this change is probably necessary for protein dimerization. results interaction of s100a8 and s100a9 in the presence of c...

Introduction: Proliferation of cancer cells and the potential of metastasis depend on the activity of different biomarkers such as proliferative ones. Proliferative biomarkers including ki-67, cyclin E1, cyclin D1, p27, and p21 were analyzed through immunohistochemistry (IHC) in previous studies. Methods: The current study aimed at investigating the utilizing role of RT-PCR in studying prolife...

breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...