نتایج جستجو برای: biological active heterocyclic pyridazinone syntheticic

تعداد نتایج: 885028  

2016
SOURAV DE

Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more heteroatoms in their structure. They may be cyclic or non-cyclic in nature. Heterocyclic compounds have a wide range of application. They are predominantly used as pharmaceuticals, agrochemicals, and veterinary products. They also find applications as sanitizers, developers, antioxidants,...

Journal: :Zeitschrift fur Naturforschung. Section C, Biosciences 1974
E de Frenne J Eberspächer F Lingens W Schäfer

Abbreviations: Pyrazon, 5-amino-4-chloro-2-phenyl-3 (2H) pyridazinone; o-methyl-pyrazon, 5-amino-4-chloro-2(2-methylphenyl)-3(2H)-pyridazinone; m-methyl-pyrazon, 5-aminoj4-chloro-2(3-methylphenyl) 43 (2H) -pyridazinone; p-methyl-pyrazon, 5-amino-4-chloro-2(4-methylphenyl) -3 (2H) pyridazinone. Requests for reprints should be sent to Prof. Dr. F. Lingens, Institut für Mikrobiologie und Molekular...

2003
Mohammad Asif Anita Singh

Pyridazin-3-one, a saturated or unsaturated form of pyridazine with carbonyl group on third carbon, has been considered as a magic moiety (wonder nucleus) which posses almost all types of biological activities. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Present a...

Journal: :Molecules 2007
Khadijah M Al-Zaydi Rita M Borik

The reaction of methyl ketones 1a-g with dimethylformamide dimethylacetal (DMFDMA) afforded the enaminones 2a-g, which were coupled with diazotized aromatic amines 3a,b to give the corresponding aryl hydrazones 6a-h. Condensation of compounds 6a-h with some aromatic heterocyclic amines afforded iminoarylhydrazones 9a-m. Enaminoazo compounds 12a,b could be obtained from condensation of 6c with s...

2009
Karnam J. R. Prasad

Heterocyclic compounds are very widely distributed in nature and are essential to life as they play a vital role in the metabolism of living cells. There are a vast number of pharmacologically active heterocyclic compounds of which many are in regular therapeutic usage. Among various heterocyclic compounds, quinoline-based drugs such as quinine, chloroquine, pamaquine and quinacrine are well kn...

2010
Vikas Sharma Pradeep Kumar Devender Pathak

Heterocyclic compounds are those cyclic compounds in which one or more of the ring carbons are replaced by another atom. The non-carbon atoms in such rings are referred to as ‘‘heteroatoms.’’ Such bicyclic heterocyclic compounds containing pyrrole ring with benzene ring fused to a,b-position are known as Indoles. Indole has a benzene ring and pyrrole ring sharing one double bond. It is a hetero...

2016

Four pyridazinones (2-5) were synthesized by the reaction of 3-benzoylpropionic acid with the corresponding hydrazines. These pyridazinones were further derivatized with appropriate aromatic aldehydes in the presence of piperidine to obtain the desired compounds (6-13). The chemical structures of the synthesized pyridazinones were elucidated on the basis of their spectral analysis (IR, 1H-NMR, ...

2013
Rajiv Dua Suman Shrivastava S. K. Sonwane S. K. Srivastava

Abstract: Heterocyclic chemistry offers an example for the lack of distinct demarcations; in fact, it pervades the plurality of the other chemical disciplines. Heterocycles are inextricably woven into the life processes. The vital interest of the pharmaceutical and agrochemical industries in heterocycles is often connected with their natural occurrence. Synthetic chemistry provides cornucopia o...

Journal: :Journal of enzyme inhibition and medicinal chemistry 2011
Asif Husain Sushma Drabu Nitin Kumar M Mumtaz Alam Aftab Ahmad

A series of pyridazinone derivatives (19-34) were synthesized with an aim to synthesize safer anti-inflammatory agents. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation (LPO) actions. The percentage inhibition in edema at different time intervals indicated that compounds 20, 26, 28 and 34 exhibited good anti-inflammatory potential, comparab...

Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their s...

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