A device model of biological molecule sensors based on semiconductor nanowires has been developed. This model of a bioFET is based on the concept of the electrolytic absolute electrode potential. From that starting point a semiconductor device model of the nanowire solution biomolecule system was derived. The model includes the Gouy-Chapman-Stern model of the salt solution double layer, site bi...

In this work, we present a computational methodology for predicting the change in signal (conductance sensitivity) of a nano-BioFET sensor (a sensor based on a biomolecule binding another biomolecule attached to a nano-wire field effect transistor) upon binding its target molecule. The methodology is a combination of the screening model of surface charge sensors in liquids developed by Brandbyg...

In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the biosample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolecu...

In this work the properties of a biotin-streptavidin BioFET have been studied numerically with homogenized boundary interface conditions as the link between the oxide of the FET and the analyte which contains the bio-sample. The biotin-streptavidin reaction pair is used in purification and detection of various biomolecules; the strong streptavidin-biotin bond can also be used to attach biomolec...

the transformation of biochemical information into a physical or chemical signal is the basic idea behind a biosensor. the efficient detection of charged biomolecules by biosensor with appropriate device has caught tremendous research interest in the present decade. the present work is related to the simulation study of the performance of a functionalized surface of a biologically sensitive fie...

Electronic devices are becoming increasingly used in chemical- and bio-sensing applications and therefore understanding the silica-electrolyte interface at the atomic scale is becoming increasingly important. For example, field-effect biosensors (BioFETs) operate by measuring perturbations in the electric field produced by the electrical double layer due to biomolecules binding on the surface. ...

Biologically inspired sensory solutions utilize highly developed organs of perception that are evolutionary tuned towards compounds correlated to ecological functions. After millions of years of “survival of the fittest” insects, e.g., are trained to detect specific compounds that serve reliably as cues to find hosts and mating partners, or to avoid enemies and competitors. The multitude of ins...

• The Gouy-Chapman-Stern layer model combines the Helmholtz and diffuse double of Gouy-Chapman to explain development double-layer capacitance on sensor’s surface. Site-binding is used describe surface charge developed at oxide/electrolyte interface. This paper presents a new methodology that these two theories, our method applied AAs (amino acids) immobilized sensor Moreover, simulation work s...

We experimentally investigate the influence of non-linear electrolytic screening by electric double layer (EDL) and its impact on field-effect transistor (FET) sensitivity to charged (bio)molecules. use DNA hybridization a PNA capture probe as model system. By co-depositing positively or negatively blocker molecules together with probes SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xm...