The objective of our work is to improve the osseointegration of titanium (and its alloys) used in dental and orthopedic applications. To do this, we have been coating these metals with glasses whose compositions are based upon Bioglass®, which is a bioactive glass developed by Hench et al. Bioactive glasses have the property of forming an apatite layer (and therefore can chemically bond to bone...

Porous Ti-6Al-4V scaffolds fabricated by means of selective laser melting (SLM), having controllable geometrical features and preferable mechanical properties, have been developed as a class of biomaterials that hold promising potential for bone repair. However, the inherent bio-inertness of the Ti-6Al-4V alloy as the matrix of the scaffolds results in a lack in the ability to stimulate bone in...

In this research work, the original 45S5 bioactive glass was modified by introducing zinc and/or strontium oxide (6 mol%) in place of calcium oxide. Sr was added for its ability to stimulate bone formation and Zn for its role in bone metabolism, antibacterial properties, and anti-inflammatory effect. The glasses were produced by means of melting and quenching process. SEM and XRD analyses evide...

BACKGROUND AND PURPOSE Cementless total hip arthroplasty is currently favored by many orthopedic surgeons. The design of the porous surface is critically important for long-term fixation. We examined the clinical and radiographic outcome of the cementless titanium hip implant with a bottom coating of apatite-wollastonite containing bioactive glass ceramic. METHODS We retrospectively reviewed ...

We conducted histologic and histomorphometric studies to evaluate the osteointegration of gradient coatings composed of bioactive glass and nanohydroxyapatite (BG-nHA) on titanium-alloy orthopaedic implants and surrounding bone tissue in vivo. Titanium-alloy implants with a gradient coating (gradient coating group), uncoated implants (uncoated group), and implants with a conventional hydroxyapa...

Silicate-based glasses with thermal expansion coefficients that match those of Ti6A14V were prepared and used to coat Ti6A14V by a simple enameling technique. Bioglass (BG) or hydroxyapatite (HA) particles were embedded on the coatings in order to enhance their bioactivity. HA particles were immersed partially during heating and remained firmly embedded on the coating after cooling. There was n...

objective: one of the major issues in bone tissue engineering is the design and fabrication of bioactive, bioresorbable porous 3d scaffolds capable of maintaining their structure and integrity over a predictable period of time. one such approach is the fabrication of composite scaffolds. methods: in this study we present fabrication and characterization of novel silk/bioglass-composite scaffold...

Bioactive glass is used as both a bone filler and as a coating on implants, and has been advocated as a potential osteogenic scaffold for tissue engineering. Rat-derived mesenchymal stem cells (MSCs) show elevated levels of alkaline phosphatase activity when grown on 45S5 bioactive glass as compared to standard tissue culture plastic. Similarly, exposure to the dissolution products of 45S5 elev...

Bioglass-graphene oxide composites can be served as a high-potential candidate for biomedical applications due to its specific mechanical properties. In this study, the 45S5 bioactive glass (BG) - graphene oxide (GO) composite containing 2 wt. % GO was coated on titanium alloy via electrophoretic deposition process (EPD). The synthesized GO was incorporated into BG coating to improve the mechan...

Bioactive glass is composed mainly of silica, sodium oxide, calcium oxide and phosphates. The bone-bonding reaction results from a series of reactions in the glass and its surface (Hench & Wilson, 1984). When granules of bioactive glass are inserted into bone defects, ions are released in body fluids and precipitate into a bone-like apatite on the surface, promoting the adhesion and proliferati...