BACKGROUND AND AIMS Rapid virologic response is the best predictor of sustained virologic response with dual therapy in genotype-1 chronic hepatitis C, and its evaluation was proposed to tailor triple therapy in F0-F2 patients. Bio-mathematical modelling of viral dynamics during dual therapy has potentially higher accuracy than rapid virologic in the identification of patients who will eventual...

statement of problem: the guided bone regeneration (gbr) technique does not always produce consistent results. bone filling within the space provided by the membrane can be incomplete. purpose: the aim of this study was to evaluate the effect of a collagen membrane (bio-gide) in combination with or without deproteinezed bovine bone mineral (bio-oss) on the healing of calvarial defects in rabbit...

BACKGROUND Plants are considered as promising sources of new antibacterial agents as well as bioassay guided fractionation. OBJECTIVES In the present work, the antibacterial properties, especially against methicillin-resistant Staphylococcus aureus (MRSA), of Bromus inermis inflorescence was studied, using the bioassay guided fractionation as well as the bio-autographic method. MATERIALS AN...

In the course of screening of plant extracts for anti-influenza viral activity, 50% aqueous methanolic extract exhibited antiviral activity against influenza virus A. Bio-assay guided fractionation of the extract led to the indication of the presence of condensed tannins as the active constituents. This was confirmed by chemical tests as well as by thin layer chromatographic comparison with kno...

Objective To evaluate the usefulness of a third-generation PTH assay in the diagnosis of primary hyperparathyroidism (PHPT). Subjects and methods Forty-one PHPT patients (4 men and 37 women) with 61.2 ± 10.9 (mean ± SD) years, were studied and had PTH levels measured with two different methods using the same immunochemiluminescent assay plataform (Elecsys 2010 System, Roche). We compared a se...

Experimental designs which prescribe either too few or too many animals per assay are wasteful, and it is important that experimenters in planning bio-assays use the number of animals coDsistent with the statistical precision actually desired in the results. The general philosophical treatment of experimental design, as noted by Fisher (1949), places controls on treatments, treatment combinatio...