The Bingel functionalisation of C(60) with a structurally novel tether equipped with three reactive malonate groups afforded a C(2v)-symmetrical e(edge),e(face),trans-1 trisadduct in a complete regioselective manner and in an excellent yield of 65%. The [60]fullerene trisadduct showed pronounced ability to crystallise and gave X-ray quality single crystals for analysis.

With the uptake of serum treatment for diphtheria from the end of the 19th century onwards, deaths from the disease fell dramatically, albeit, less dramatically in countries, such as the UK, in which serum treatment had not been adopted wholeheartedly. The development of serum therapy of humans – in a race between the Berlin Institute for Infectious Diseases and Emile Roux and his colleagues at...

We have studied the relative stabilities of Bingel-Hirsch non-IPR endohedral metallofullerene monoadducts having one, two, or three adjacent pentagon pairs. The most stable addition always leads to an open adduct and never occurs on [5,5] bonds. Our results show that the thermodynamics of the addition is governed by the additive local aromaticity of the rings of the final adducts.

Two cyclopropane derivatives of N@C60 were synthesised by well-controlled Bingel reactions, in which 94% of the spin centres were retained, as confirmed by a series of quantitative electron spin paramagnetic resonance (EPR) measurements. Further study on the influence of the DBU catalyst base revealed a spin loss mechanism through a fullerene-DBU diradical.

The addition of N-(diphenylmethylene)glycinate esters (Ph2C=NCH2CO2R) to [60]fullerene under Bingel conditions gives [60]fullerenyldihydropyrroles and not methano[60]fullerenyl iminoesters [C60C(CO2R)(N=CPh2)] as previously reported. Unequivocal evidence for the structure of C60C(CO2Et)(N=CPh2) was provided by INADEQUATE NMR studies on 13C enriched material. New mechanistic details are proposed...

Four methanofullerene derivatives, with phosphonate or sulfone groups attached to a C(60) core through a Bingel procedure, were synthesized to probe their stability upon electrolytic reduction. Derivatives 1 and 2 are the most stable upon electroreduction and do not exhibit retro-cyclopropanation reactions until more than three electrons per C(60) derivative are transferred. The cyclopropane ri...

We report on the synthesis of C60 and C70 monoadducts at room temperature through Bingel reaction; employing acetylacetone as ligand; in presence DBU (1,8-Diazabicyclo [5.4.0] undec-7-ene), carbon tetrabromide (CBr4), o-dichlorobenzene. Diacetylmethane-[C60-Ih]-fullerene-[5,6] diacetylmethane-[C70-D5h]-fullerene-[5,6] were obtained with yields 69% 44%, respectively. The products purified by col...

Carbon nanotubes have unique properties like high stability, high surface to mass ratio and so on which make them suitable for medicinal purpose applications. Treatment of cancer by organoplatinum agents like Cisplatin has become unresponsive in most cases due to low distribution of drug in biological fluids, inability of drug to cross cellular membranes and low stability in biological environm...

The regioselective polyfunctionalization of highly symmetric spherical I h -C 60 is extremely challenging and usually leads to the formation regioisomeric mixtures not amenable for high-pressure liquid chromatography (HPLC) purification. Here, we pioneer use tetragonal prismatic nanocapsules perform selective Diels-Alder (DA) functionalization encapsulated using acenes. supramolecular mask allo...