background: hypertrophic cardiomyopathy is a genetic disorder with a prevalence rate of 0.2% in the general population. it comes from mutations in sarcomeric proteins. cardiac myosin-binding protein c3 is one of the critical genes in hypertrophic cardiomyopathy (hcm) and sudden cardiac death, accounting for about 20% of hcm-causing mutations. genetic testing is recommended in patients with hcm....

background: serum levels of lipocalin 2 (lcn 2) and retinol-binding protein-4 (rbp 4), increase in type 2 diabetes mellitus (t2dm). we sought to determine whether serum lcn 2 and rbp 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. methods: forty-five type 2 diabetic patients from iranian diabetic association in tehran, iran in 2013 were randomly rec...

objective(s): the periodic binding of protein expressed by mycobacterium tuberculosis h37rv with the host cell receptor molecules i.e. fibronectin (fn) is gaining significance because of its adhesive properties.  the genome sequencing of m. tuberculosis h37rv revealed that the proline-glutamic (pe) proteins contain polymorphic gc-rich repetitive sequences (pgrs) which have clinical importance i...

objective(s):psoriasis is an autoimmune disease that appears on the skin. although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. the aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human to find valuable biomarkers. materials and methods: in a case-control s...

Objective(s) Staphylococcus aureus is a foremost source of numerous nosocomial and community acquired infections. Antibiotic therapy for vancomycin resistant S. aureus (VRSA) can not promise the eradication of infections. Since adhesion is the major route of infections, adhesin based vaccine could suppress S. aureus infections. Fibronectin binding protein A (FnBPA) and clumping factor A (ClfA)...

the aim of this investigation was conducted to proteomic analysis of plasma obtained from pregnant women who destined to develop late-onset preeclampsia without intrauterine growth restriction (iugr) during 16 th week of gestation. plasma was obtained from primiparous women during 16 th week of gestation. 2-de proteomic analysis was done for plasma from 11 healthy pregnant women and 11 women wh...

background one disadvantage of expressing heterologous proteins in escherichia coli is that the proteins are frequently expressed as insoluble inclusion bodies. to avoid this problem, heterologous proteins are typically expressed as a fusion protein. maltose binding protein (mbp) is one of the widely used partners for production of recombinant fusion proteins in e. coli. mbp is among the most e...

conclusions the results of the present study indicate the presence of the pvl and fnb genes in the strains of s. aureus isolated from clinical specimens collected from the patients admitted to teaching hospitals in qazvin. considering the clinical significance of these organisms, and their potential in threatening public health systems, the identification, treatment, and infection control manag...

background:isolates of staphylococcus aureus express a myriad of adhesive surface proteins that play important role in colonization of the bacteria on nasal and skin surfaces, beginning the process of pathogenesis. the aim of this study was to screen several of the microbial surface components recognizing adhesive matrix molecules (mscramms) genes among the isolate of s. aureus from hospitalize...

the antidiuretic effect of arginine vasopressin (avp) is mediated by the vasopressin v2 receptor. the docking study of avp as a ligand to v2 receptor helps in identifying important amino acid residues that might be involved in avp binding for predicting the lowest free energy state of the protein complex. whereas previous researchers were not able to detect the exact site of the ligand-receptor...