نتایج جستجو برای: binding p type atpase

تعداد نتایج: 2782987  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Jonathan A Coleman Anna L Vestergaard Robert S Molday Bente Vilsen Jens Peter Andersen

ATP8A2 is a P(4)-ATPase ("flippase") located in membranes of retinal photoreceptors, brain cells, and testis, where it mediates transport of aminophospholipids toward the cytoplasmic leaflet. It has long been an enigma whether the mechanism of P(4)-ATPases resembles that of the well-characterized cation-transporting P-type ATPases, and it is unknown whether the flippases interact directly with ...

2017
Gracian Tejral Bruno Sopko Alois Necas Wilhelm Schoner Evzen Amler

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases reveals that binding of ATP to the N-domain connected by a hinge to the P-domain is much too far away from the Asp369 to allow the...

Journal: :Journal of Biological Chemistry 2002

Journal: :Circulation research 1989
R F Kauffman B G Utterback D W Robertson

[3H]LY186126, an analogue of the cardiotonic agent indolidan, was shown to bind reversibly and with high affinity (Kd = 4 nM) to a single class of binding sites within canine myocardial vesicles. Binding site density measured in various cardiac membrane fractions correlated well with Ca2+-ATPase activity (r = 0.94; p less than 0.01), but not with Na+,K+-ATPase or azide sensitive ATPase, indicat...

2016
Gregory M. Goldgof Jacob D. Durrant Sabine Ottilie Edgar Vigil Kenneth E. Allen Felicia Gunawan Maxim Kostylev Kiersten A. Henderson Jennifer Yang Jake Schenken Gregory M. LaMonte Micah J. Manary Ayako Murao Marie Nachon Rebecca Stanhope Maximo Prescott Case W. McNamara Carolyn W. Slayman Rommie E. Amaro Yo Suzuki Elizabeth A. Winzeler

The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroindolones and that these mutations are sufficient for resistance. KAE609 resistance mutations in ScPMA1 do n...

Journal: :Japanese Journal of Pharmacology 1996

Journal: :The Biochemical journal 2004
Juha Okkeri Liisa Laakkonen Tuomas Haltia

In P-type ATPases, the nucleotide-binding (N) domain is located in the middle of the sequence which folds into the phosphorylation (P) domain. The N domain of ZntA, a Zn2+-translocating P-type ATPase from Escherichia coli, is approx. 13% identical with the N domain of sarcoplasmic reticulum Ca2+-ATPase. None of the Ca2+-ATPase residues involved in binding of ATP are found in ZntA. However, the ...

Journal: :The Journal of experimental biology 1996
M Maeda K Kubo T Nishi M Futai

The gastric H+/K(+)-ATPase is a P-type ATPase that is specifically expressed in gastric parietal cells and is responsible for acid secretion into the stomach. We have found one or more gastric mucosal nuclear proteins that recognize a sequence motif in the 5'-upstream regions of the H+/K(+)-ATPase alpha- and beta-subunit genes. This gastric motif, (G/C)PuPu(G/C)NGAT(A/T)PuPy, may be a binding s...

Journal: :Plant & cell physiology 2002
Toshinori Kinoshita Ken-ichiro Shimazaki

Blue light (BL) activates the plasma membrane H(+)-ATPase via phosphorylation of the C-terminus with concomitant binding of 14-3-3 protein to the terminus in stomatal guard cells. However, the binding site and role of 14-3-3 protein in this physiological response have not been elucidated. We investigated the above using synthetic phosphopeptides designed from the C-terminus of Vicia H(+)-ATPase...

2005
David L. Stokes

ATP-driven ion pumps fall into three families, which are known as F-type (named after F1/F 0 ATPase), V-type (named after the vacuolar H + pump), and P-type (those forming a covalent phosphoenzyme). This review focuses on P-type ion pumps, a family that shares both amino acid homologue and a basic reaction mechanism. The family includes a wide range of species (including bacteria, yeast and mam...

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