Methods Clinical files of the 335 patients referred to the FAU of a Portuguese University Hospital for suspected food allergic reactions between January 2010 and April 2014 were retrospectively reviewed; those with suspicion of SH were selected. Patients’ demographics, medical history and SH diagnostic procedures reviewed. The allergy work-up was considered complete when an open food challenge ...

Last week, the French Health Ministry reported that six patients taking part in a Phase 1 clinical trial administered by Portuguese drug manufacturer Bial for an alleged painkiller containing cannabinoids were rushed to a local hospital after experiencing adverse events. The situation deteriorated over the weekend when one of the patients who was in a coma passed away while the others remained ...

The isolation, structural elucidation and biological activities of oligosporon (1), oligosporol A (2) and oligosporol B (3), three new antibiotics from cultures of the predacious deuteromycete, Arthrobotrys oligospora, are reported. The structures were elucidated by means of high resolution mass and high field N M R spectroscopy. The compounds exhibited weak antimicro­ bial, cytotoxic and hemol...

TOPIC: Pulmonary Vascular Disease TYPE: Original Investigations PURPOSE: To study (i) the pharmacokinetics (PK) and pharmacodynamics (PD) of Zamicastat its main metabolites (ii) intrinsic extrinsic effects on PK PD profiles. METHODS: Data pooled from six phase-I clinical studies in healthy volunteers (N=366) ≥18 years old both genders were integrated, where oral doses ranging 5 to 2400 mg 1200 ...

I start with a basic tutorial on Arti cial Evolution and then show the simplest possible way of implementing this with the Micro bial Genetic Algorithm I then discuss some shortcomings in many of the basic assumptions of the orthodox Genetic Algorithm GA com munity and give a rather di erent perspective The basic principles of SAGA Species Adaptation GAs will be outlined and the con cept of Neu...

Transdermal diffusion studies of a polyherbal ointment were carried out in vito using franz- Diffusion cell and microbial one inhibition diameter as drug release monitoring parameters. Out of the three ointment base prepared, (Hydrocarbon Base (HB), surfactant Base (SB), Surfactant Base + (Penetration Enhancer (10 % DMSO) SBPE), we observed that SBPE possesses maximum drug release capacity, as ...

The effects of Trigonella foenum graecum (TF) and Foeniculum vulgare (FV) seeds powder on antimicro-bial activity and performance of broiler chickens were studied. Based on a completely randomized design, 240 broiler chicks (Ross 308) were assigned to 4 treatments and 4 replicates. The treatments were a basal diet (control, T 1), T 1 plus 0.5% TF (T 2), T 1 plus 0.5% FV (T 3) and TFFV (0.25% TF...

the effects of trigonella foenum graecum (tf) and foeniculum vulgare (fv) seeds powder on antimicro-bial activity and performance of broiler chickens were studied. based on a completely randomized design, 240 broiler chicks (ross 308) were assigned to 4 treatments and 4 replicates. the treatments were a basal diet (control, t 1), t 1 plus 0.5% tf (t 2), t 1 plus 0.5% fv (t 3) and tffv (0.25% tf...