Aim: To assess the prevalence of hepatitis C virus among patients beta-thalassemia. Methods: We enrolled 200 beta-thalassemia in this observational cross sectional study conducted at Department Pathology, Jinnah Medical College/District Specialist Naseerullah Babar Memorial Hospital, Peshawar duration from March, 2022 to August, 2022. determined frequency HCV and assessed association with age g...

Hemoglobinopathy refers to a disease involving qualitative or quantitative defect of the structure synthesis haemoglobin molecules. The HaemoglobinS- beta thalassemia occurs in heterozygotes individual with beta-thalassemia and HaemoglobinS gene. A 29-year-old man came severe anemia, thrombocytopenia, history repeated blood transfusions. Physical examination showed pale conjunctiva, pansystolic...

background and objectives: beta-thalassemia continues to be a cause of significant burden to the society particularly in the poorer developing countries. although sophisticated methods of screening have become available, a hunt for a cheap, rapid, objective screening method still remains elusive. thus, the objectives are to study the validity of naked-eye-single-tube-osmotic-fragility-test (nes...

Homozygous thalassemia is due to inherited unbalanced synthesis of the alpha- or beta-chains of hemoglobin. Clinical severity may be in part related to the extent of alpha:beta imbalance. Two families are presented that illustrate this concept. Thalassemia in these individuals was evaluated by clinical and genetic criteria. The relative rates of alpha- and beta-chain synthesis in their reticulo...

Oxidative damage induced by free globin chains has been implicated in the pathogenesis of the membrane abnormalities observed in alpha and beta thalassemia. We have evaluated transport of Na+ and K+ in erythrocytes of patients with thalassemias as well as in two experimental models that use normal human red blood cells, one for alpha thalassemia (methylhydrazine treatment, alpha thalassemia lik...

Background: Hb A2 is elevated in subjects with beta thalassemia minor but small percent of carriers have normal Hb A2 with elevated levels of HbF (2-10%). This type of thalassemia is called delta beta thalassemia, and can be missed in pre-marriage hematologic consults or screening which leads to increased risk of child birth with beta thalassemia major. Materials and Methods: In this prospe...

Co-inheritance of alpha-thalassemia with homozygosity or compound heterozygosity for beta-thalassemia may ameliorate beta-thalassemia major. A wide range of clinical phenotypes is produced depending on the number of alpha-thalassemia alleles (-alpha/alphaalpha --/alphaalpha, --/-alpha). The co-inheritance of beta-thalassemia with alpha-thalassemia with a single gene deletion (-alpha/alphaalpha)...

background: hepatitis c virus (hcv) is the major cause of post-transfusion hepatitis infection (pth). patients with thalassemia major are at high risk of hepatitis c due to the blood transfusion from donors infected by hcv. the aim of this study was to detect the prevalence of anti-hcv antibodies and risk factors in multitransfused thalassemic patients in isfahan-iran to establish more preventi...

beta-thalassemia, by its high frequency and heterogenecity, constitues a real problem of health in iran. aboute 13 beta globin mutations encompass 70-90% of mutations spectrum in iran, the rest are rare or unknown. in this study six mutations of the codon ivsi-130(g-c), fr16 (-c), codon35 (-c), fr23/24(-g), codon8 (+g) and codon 20 (gtg-gag) were recognized and added to spectrom of beta globin ...