conclusions these findings indicated the association of the hbsag titer and serum ifnar2 in hbsag clearance in hepatitis b virus- infected patients. in consequence, immune mechanisms related to ifn-α/β signaling might be responsible in chb outcome. background loss of hepatitis b surface antigen (hbsag) in chronic hepatitis b (chb) infection is a favorable outcome. type i interferon (ifni) has a...

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

Background: Phytoestrogens, a group of plant-derived polyphenolic compounds have recently come into considerable attention due to the increasing information on their potential adverse effects in human health. Some of phytoestrogens show estrogenic activity that may be carcinogenic for human. In the present study, we investigated the transcriptional effects of variety of phytoestrogens&nbsp...

serotonin receptors are involved in pathophysiology of schizophrenia and may mediate other neurotransmitter effects. we investigated serotonin receptors gene expression in peripheral blood mononuclear cells (pbmc) of naïve schizophrenic patients, before and after treatment. also serotonin receptor gene expression was compared in two treatment groups including haloperidol and olanzapine. the pbm...

Background & Objective: Gliomas are the most common type of primary intracranial tumors in adults. The expression of estrogen receptors varies in different grades of glial tumors, and some studies have suggested that this expression might have a prognostic value. It seems that estrogen receptor expression negatively correlates with the histological grade of gliomas. In the pres...

Transforming growth factor beta (TGFβ1, β2, and β3) are 25 kDa disulfide-linked homodimers that regulate many aspects of cellular functions, consist of proliferation, differentiation, adhesion and extracellular matrix formation. TGFβs mediate their biological activities by binding of growth factor ligand to two related, functionally distinct, single-pass transmembrane receptor kinases, known as...