Four patients with multiple bronchial stenoses are described. Two patients had pulmonary sarcoidosis, the third probably had berylliosis, and the aetiology in unknown in the fourth. Their symptoms included dyspnoea, wheeze, stridor, and frequent chest infections. The bronchial stenoses were demonstrated by tomography, flow volume studies, and bronchoscopy. Corticosteroids were ineffective but i...

BACKGROUND Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP beta-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker. METHODS In this repo...

This Guideline provides the clinical diagnostic criteria for beryllium sensitization and chronic beryllium disease (CBD; old term = berylliosis), based on the latest available medical literature and consultation with leading experts in the field. This Guideline does not address exposure prevention, workplace safety, or treatment. In addition, this Guideline is not intended to supplant all adjud...

OBJECTIVE Data from surveys of the general workforce and new employees at a beryllium manufacturer were used to evaluate the performance of the beryllium blood lymphocyte proliferation test (BeBLPT). METHODS Over 10,000 results from nearly 2,400 participants collected over 12 years were analyzed using consistent criteria to describe the performance characteristics of the BeBLPT. RESULTS App...

ence, emphasis was placed on what is new and what is newly important with respect to a selected number of occupational diseases of the chest. Discussion was developed around features of typical and unusual example of coal dust pneumoconiosis, silicosis, siderosis, asbestosis, reactions to fibrous silicates and plastic, berylliosis, aluminosis, farmer’s lung, lipid pneumonitis and hair spray the...

Hypersensitivity to beryllium (Be) is found in 1-16% of exposed workers undergoing immunological screening for beryllium disease using the beryllium lymphocyte proliferation test (BeLPT). However, only approximately 50% of BeLPT-positive workers present with lung granulomas (i.e. berylliosis). As berylliosis is associated with the human leukocyte antigen (HLA)-DP supratypic marker DPGlu69, the ...

An asymptomatic cremator was found incidentally to have lymphocytic alveolitis by bronchoalveolar lavage, and the basis for this finding was investigated. No known causes of lymphocyte alveolitis including sarcoidosis, hypersensitivity pneumonitis, berylliosis, tuberculosis, or fungal diseases of the lung were found. By exclusion, therefore, exposure to formaldehyde and/or to compounds in the r...