Benzotriazole (BTR) and benzothiazole (BTH) derivatives are used in a wide variety of industrial and consumer products and have been reported to occur in the environment. Owing to a lack of analytical methods, human exposure to BTRs and BTHs is still unknown. Therefore, a liquid chromatography-electrospray ionization tandem mass spectrometry (LC–ESI(+)MS/MS) method was developed for simultaneou...

Fragment based Quantitative structure activity relationship (QSAR) analysis on reported 25 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole dataset as antitubercular agents were carried out. Molecules in the current dataset were fragmented into six fragments (R1, R2, R3, R4, R5, R6).Group based QSAR Models were derived using Multiple linear regression (MLR) analysis and selected on the bas...

Due to its beneficial natural and pharmacological properties, heterocyclic element analogues derivatives have recently received a lot of attention. One the frequently occurring nuclei in both marine grow solutions is benzothiazole. A favoured bicyclist band method with numerous utilizations It well known for exhibiting broad variety activities, including those that are anticancer, antiviral, an...

Despite the widespread use of benzotriazoles and benzothiazoles and the occurrence of these compounds in wastewater treatment plants (WWTPs), no earlier study has comprehensively examined their fate in WWTPs. In this study, an integrated liquid chromatography-tandem mass spectrometry (LC–ESI(+)MS/MS) method was developed and validated for simultaneous determination of four benzotriazoles and fo...

On the basis of exhaustive literature review, it has been found that benzothiazole derivatives have good potential to exhibit anticancer activity15-17. So the present study involves the synthesis of 2,6-disubstituted benzothiazole followed by preliminary cytotoxicity screening against three human cancer cell lines( MCF-7, HeLa and MG63) using MTT assay at 48 h of exposure.

The synthesis of a new type of pentacyclic benzothiazolium compound 6,13-dihydropyrazino[2,1-b:5,4-b ́]bis(1,3-benzothiazole)-7,14-diiumdibromide (2), is reported. Compound 2 was prepared by dimerization of 2-(bromomethyl)benzothiazole. Quantum chemical calculation studies have been carried out on the structures of possible isomers of 2, as well as the products of its deprotonation reactions.

Benzothiazole-2-sulfonate (BTSO3) is one of the side products occurring in 2-mercaptobenzothiazole (MBT) production wastewater. We are the first to isolate an axenic culture capable of BTSO3 degradation. The isolate was identified as a Rhodococcus erythropolis strain and also degraded 2-hydroxybenzothiazole (OBT) and benzothiazole (BT), but not MBT, which was found to inhibit the biodegradation...

The present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular conjugates. It involved three-component condensation of the appropriate bromoacetamide benzothiazole, sodium azide and 4-alkyl/aryl-5-(2-fluorophenyl...

4-methylaniline in chlorobenzene reacted with sulphuric acid, sodium thiocyanate and sulfuryl chloride to give 2-amino-6-methyl benzothiazole. This 2-amino-6methyl benzothiazole was later further reacted with 2-(2,2difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride in the presence of Dichloromethane and anhydrous Pyridine to afford 2-(2,2-difluoroethoxy)-N-(6methylbenzo[d]thiazole-2...

Benzotiazole and pyrimidine have been reported to act as effective pharmacophores. However, much less work as been carried out on these heterocycles fused with each other. In the present study, we report the synthesis of a series of 8-chloro-3(phenylcarbonoimidoyl)-10a-H-pyrimido [2,1-b][1,3]benzothiazole-2-thiol. This series was synthesized by the reaction of 8-chloro-2-sulfanyl-10a-H-pyrimido...