penicillin acylase (ec 3.5.1.11) has been a target of study for a long time because of its pivotal role in the deacylation of the penicillin into the 6- aminopenicillanic acid (6-apa) and the side-chain organic acids. this property of penicillin acylase has been exploited commercially for large scale production of 6-apa, which is the key intermediate in the manufacture of semi-synthetic penicil...

individual approaches to the diagnosis and management of penicillin allergy are practiced    by clinicians.   this cross-sectional survey of physicians was aimed at exploring their ways of dealing with diagnosis and management of penicillin g allergy.   of the 235 respondents, 63% believed patients’ self-reported history of penicillin allergy and avoided using penicillin g;     97% do so for pa...

The penicillin allergy is being increasingly recognized as a significant public health problem. Immunological responses to penicillin and other beta-lactam antibiotics are classified as immediate and non-immediate responses. This research aimed to develop an enzyme-linked immunosorbent assay (ELISA) for the detection of the reactive antibody value against penicillin in various species of animals...

for many years , penicilline was the only drug of choice for treatment of gonorrhoeae, but the increased incidence of this disease in many parts of the world and the failure of penicilline-therapy against it has brought the theory of penicilline-resistant strains of gonococcus. on the other hand , the increased incidence of asymptomatic infection of gonorrhoeae especially in females has been co...

beta-lactams are a group of antibiotics with a broad spectrum of both gram-negative and gram-positive coverage. the goal of this study is to evaluate the results from studies regarding ig-e mediated hypersensitivity to penicillin and cross-reactivity with other beta-lactams. review was conducted of both retrospective and prospective studies by searching in pubmed and medline for the original an...

streptococcuscus beta hemolytic group a is the most important pathogen causing which may lead to purulent and non purulent angina. rheumatic fever is the most important complication that is the cause of 30% to 40% of cardiac disease and disablement. this study was performed to evaluate prevalence of streptococcuscus beta hemolytic group a and estimate role of clinical findings in children with ...

BACKGROUND The intermittent unavailability of penicilloyl-polylysine since September 2000 has focused interest on commercial anti-penicillin IgE fluorometric enzyme immunoassay (FEIA) tests to evaluate penicillin allergy. There has been no published comparison of commercial anti-penicillin IgE FEIAs and penicillin skin testing performed in the United States. OBJECTIVE To determine whether the...

The activities of ertapenem (MK-0826) and eight other agents against a range of penicillin-susceptible and -resistant pneumococci were tested by determination of MICs by the microdilution method and by the time-kill methodology. For 125 penicillin-susceptible, 74 penicillin-intermediate, and 86 penicillin-resistant pneumococci, the MICs at which 50% of isolates are inhibited (MIC(50)s) and MIC(...