The title compound, C20H16N2O, (I), has been unwittingly obtained from the slow evaporation of a saturated solution of commercial benserazide hydro-chloride [benserazide, (II), being one of the principal therapeutic compounds used for the management of Parkinson's disease, mostly used in combination with levodopa]. The mol-ecule of (I) is composed of two planar 4-methyl-quinoline aromatic moiet...

objective(s): the aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. materials and methods: sprague-dawley male rats were treated with levodopa (ld), betaine (bet), levodopa plus betaine (ld/bet), levodopa plus benserazide (ld/ben), levodopa plus betaine-benserazide (ld/bet-ben), and t...

-The DOPA-decarboxylase (aromatic-L-amino acid decarboxylase) inhibitors benserazide, its active metabolite 2,3,4-trihydroxybenzylhydrazine and carbidopa are substrates of highly purified catechol-O-methyltransferase. The affinity and maximal velocity of both benserazide and trihydroxybenzyl hydrazine are extremely favourable implying that these compounds may compete as substrates for catechol-...

BACKGROUND AND PURPOSE Delayed treatment of patients with stroke with levodopa/benserazide contributes to enhanced functional recovery, but the mechanisms involved are poorly understood. The present study was designed to investigate if levodopa/benserazide treatment improves recovery of lost neurological function and contributes to tissue reorganization in the rat brain after stroke. METHODS ...

It has been shown previously that kynurenine hydrolase (L-kynurenine hydrolase, EC 3.7.1.3) is inhibited by the hydrazide Benserazide {R,, 4-4602, DL-serine 2-[(2,3,4trihydroxyphenyl)methyl] hydrazide), a compound that is used clinically in the treatment of Parkinson’s disease (Bender et al., 1977). Benserazide is a potent inhibitor of aromatic amino acid decarboxylase (L-aromatic amino acid ca...

BACKGROUND AND PURPOSE L-Threo-3,4-dihydroxyphenylserine (DOPS) is reported to increase the nerve growth factor (NGF) synthesis in cultured mouse L-M fibroblast and astroglial cells, and this effect is not blocked by treatment with decarboxylase inhibitor. NGF is suggested to play an important role in neuronal survival and regeneration under pathological conditions. We evaluated the possible pr...

The objective of the present investigation was to test the effects of benserazide/L-dopa treatment in a model of learning and memory deficits associated with early Parkinson's disease. Intra-nigral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused a lesion in the substantia nigra, compact part and a specific loss of dopamine (DA) and its metabolites in the striatum of...

BACKGROUND This study describes orthostatic and postprandial hypotension in elderly Parkinsonian patients and evaluates the effect of levodopa therapy on orthostatic and postprandial hypotension in these patients. METHODS Seventeen elderly patients with a clinical diagnosis of Parkinson's disease or Parkinsonism based on the U.K. Parkinson's Disease Society Brain Bank criteria (age range, 66-...