.......This issue marks our tenth anniversary edition of Top Picks articles from the major microarchitecture-related conferences, a tradition started in 2003 by Pradip Bose at the start of his tenure as Editor in Chief, and an issue that I think has only grown in importance in the intervening years. Over the years, Top Picks published many great articles. This year’s edition contains 11 more, a...

The design and implementation of a national computing systems Grid has become a reachable goal for both computer and computational scientists. A distributed infrastructure capable of sophisticated computational functions can bring many benefits to scientific work, but poses many challenges to computer scientists, both technical and socio-political. Technical challenges include having basic soft...

The occasion of Sydney Finegold’s 80th birthday is a time to reflect on the extraordinary life and accomplishments of this giant in the field of infectious diseases. For my contribution to this symposium, my decision was to review the most important publications in the field of infectious diseases for the year 2001. It should be acknowledged from the outset that there is a sparse contribution f...

Seasonal affective disorder (SAD) is a subtype of a mood disorder that is characterized by recurring episodes of major depression, the onset and remission of which seem to relate to particular seasons. This condition most commonly begins in autumn/ winter and fully remits by spring. While the pathogenesis is uncertain, there appears to be a relationship to light exposure and delay in the affect...

The increase in our knowledge of the immune mechanisms leading to the formation of the sarcoid granuloma unfortunately has not resolved the key question dealing with the etiologic agent(s) causing the disease. In this article, many genomes of Propionibacterium acnes or Propionibacterium granulosum were detected in specimens from 15 lymph node biopsies from 15 patients with sarcoidosis by using ...

Ten reasons are given why supersymmetry is the leading candidate for physics beyond the Standard Model. Ultimately, the experimental discovery of supersymmetric particles at future colliders will determine whether supersymmetry is relevant for TeV scale physics. The grand hope of supersymmetry enthusiasts is to connect TeV scale supersymmetry with Planck scale physics. The ten most pressing the...