نتایج جستجو برای: bcr
تعداد نتایج: 11052 فیلتر نتایج به سال:
with the present specifications for clasification, 95% of chronic myelogeneous leukaemia (cml) cases have the t(9;22), which brings the abl oncogene to the bcr region and results in a hybrid gene bcr/abl. there may be involvement of other chromosomes in 2-10%, and secondry or additional chromosome abberations may present in 60-80% during the progression of the disease. in the majority of the re...
یکی از روشهای زیر فضای کریلف برای حل دستگاه معادلات خطی روش گرادیان مزدوج (cg) است که از روش جهتهای مزدوج (cd) یا از روش لانکزوس به دست می آید. در این پایان نامه روابط بازگشتی از نوع hs و لانکزوس برای تولید جهتهای a-مزدوج را بررسی می کنیم. همچنین چگونگی به دست آوردن روشهای مانده دو مزدوج (bcr) از الگوریتم بلوکی cg را توصیف می کنیم. سپس حالتهای متفاوت روش bcr را معرفی می کنیم. نتایج عددی نشان م...
the study aimed to come up with a list of specific macroalgae species, which could be used to biomonitor specific metal elements in the coastal waters of east africa. water extraction, edta, aqua regia extraction and optimized bcr 3-step sequential extracts were used to mimic bioavailable metals under various environmental conditions. the results indicated that ulva lactuca could be used as a b...
The Bcr-Abl oncoprotein is the primary causative factor in Philadelphia chromosome-associated leukemias. The activated tyrosine kinase of the Bcr-Abl oncoprotein is the primary driving force behind its oncogenic activity. We report here that a deleted form of Bcr [Bcr(64-413)], encompassing the Abl SH2 binding domains of Bcr, reduced the phosphotyrosine content of c-Abl and Bcr-Abl within cells...
The aim of this retrospective study was to identify clinical predictors early biochemical recurrence (BCR) in patients with high-risk prostate cancer (PCa) treated carbon-ion radiotherapy (CIRT) and androgen deprivation therapy (ADT). A total 670 PCa CIRT ADT were included the study. Early BCR defined as occurring during adjuvant after or within 2 years completion ADT. Univariate multivariate a...
Chronic Myeloid Leukemia (CML) is a hematopoietic malignancy characterized by the presence ofPhiladelphia (Ph1) chromosome that results from balanced reciprocal translocation between chromosomes9 and 22 leading in the formation of bcr/abl fusion gene. The present study was conducted to evaluate cytogenetic and molecular abnormalities in CML patients at presentation and during the co...
Bcr is a serine/threonine kinase activated by platelet-derived growth factor that is highly expressed in the neointima after vascular injury. Here, we demonstrate that Bcr is an important mediator of angiotensin (Ang) II and platelet-derived growth factor-mediated inflammatory responses in vascular smooth muscle cells (VSMCs). Among transcription factors that might regulate Ang II-mediated infl...
jak2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. a single acquired point mutation – v617f – in jak2 occurs in the great majority of patients with polycythemia vera (pv) and approximately half of the patients with idiopathic myelofibrosis (imf) or essential thrombocythemia (et). in contrast, the jak2-v617f mutation is...
Small interfering RNAs (siRNAs) were designed to target the bcr-abl oncogene, which causes chronic myeloid leukemia (CML) and bcr-abl-positive acute lymphoblastic leukemia (ALL). Chemically synthesized anti-bcr-abl siRNAs were selected using reporter gene constructs and were found to reduce bcr-abl mRNA up to 87% in bcr-abl-positive cell lines and in primary cells from CML patients. This mRNA r...
مقدمه: لوسمی میلوئیدی مزمن (cml) زمانی تشخیص داده می شود که وجود کروموزوم فیلادلفیا و فیوژن های abl-bcr در بیماران اثبات شود. در این مطالعه 58 بیمار مبتلا به لوسمی میلوئیدی مزمن از نظر شیوع انواع فیوژن های abl-bcr مورد بررسی قرار گرفتند. مواد و روش ها: پس از تکمیل پرسشنامه اطلاعات پایه، نمونه خون بیماران با کسب رضایت آگاهانه گرفته شد. rna از نمونه خون استخراج شد. با استفاده از سنتز cdna و روش ...
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