PURPOSE OF THE STUDY The purpose of the study was to evaluate the capacity of the surveillance system to respond to the schedule changes in the view of TB vaccination uptake. Complications of Bacillus Calmette-Guerin (BCG) vaccination in Poland are as elsewhere uncommon. In Poland, BCG vaccination with a vaccine produced with Mycobacterium bovis BCG Moreau has been a part of the National Immuni...

various adjuvants in combination with different antigens have been utilized as a vaccine candidate against leishmaniasis. however, the search for ideal adjuvants is still pursued due to the inefficiencies of current compounds. in the present study, the effect of imiquimod, as an adjuvant, is studied with soluble leishmania antigens (sla) in balb/c mice. four groups of mice were immunized with s...

Background: Although the efficacy of Bacillus Calmette-Guerin (BCG) vaccine in the prevention of tuberculosis has been noted consistently, the use of BCG vaccine is not without risk. In this study we aimed to evaluate immunologically, children with complication of BCG vaccination in North of Iran.Materials and Methods: This case-control study began in 30 Jan 2013 and was completed in 2 Jul 2015...

Oral delivery of BCG in a lipid formulation (Liporale™-BCG) targets delivery of viable bacilli to the mesenteric lymph nodes and confers protection against an aerosol Mycobacterium tuberculosis challenge. The magnitude, quality and duration of the effector and memory immune response induced by Liporale™-BCG vaccination is unknown. Therefore, we compared the effector and memory CD4(+) T cell res...

BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccin...

Background: The BCG vaccine, used since 1921 to prevent tuberculosis (TB), considered the world's most widely used vaccine. This study aimed to investigate the frequency and the type of complications associated with Bacillus Calmette-Guérin (BCG) vaccination in Iranian children. Materials and Methods This cross-sectional study conducted for 6months among children aged up to 18 months who presen...

TO THE EDITOR—We thank Thysen et al for their cautionary perspective on BCG vaccination policy changes. Although we found improved immunogenicity of BCG vaccine in human immunodeficiency virus (HIV)–exposed infants vaccinated at 8 weeks of age, compared with immu-nogenicity among those vaccinated at birth [1], we do not recommend changes to vaccine-delivery services on the basis of these data. ...

Healthy volunteers were randomized to receive percutaneous or intradermal bacille Calmette-Guérin (BCG) vaccination. Delayed-type hypersensitivity (DTH) to tuberculin, as well as proliferative and interferon-gamma responses in peripheral blood mononuclear cells stimulated by whole cell lysates and culture filtrates of Mycobacterium tuberculosis and Mycobacterium avium-intracellulare, were compa...

background: although the efficacy of bacillus calmette-guerin (bcg) vaccine in the prevention of tuberculosis has been noted consistently, the use of bcg vaccine is not without risk. in this study we aimed to evaluate immunologically, children with complication of bcg vaccination in north of iran.materials and methods: this case-control study began in 30 jan 2013 and was completed in 2 jul 2015...