bcg (bacille calmette–guérin) vaccine is administered worldwide to prevent severe forms of tuberculosis. it is considered to be safe; however, occasional complications are seen. the most serious complication is bcgosis. we report a case of bcgosis with granulomatous hepatitis and acid-fast bacilli in liver and spleen. we treated the patient with antituberculosis drugs without any response to tr...

bacillus calmette guerin (bcg) developed by albert calmette and camille guerin in france between 1908 and 1921 contained a live attenuated strain of mycobacterium bovis and was administered worldwide to prevent tuberculosis. bcg vaccination is also administered at birth to all the newborns in iran. disseminated bcg infection after bcg vaccination is rare. here in, we report 2 new cases of disse...

In mice, natural resistance or susceptibility to infection with intracellular parasites is determined by a locus or group of loci on chromosome 1, designated Bcg, Lsh, and Ity, which controls early microbial replication in reticuloendothelial organs. We have identified by positional cloning a candidate gene for Bcg, Nramp1, which codes for a novel macrophage-specific membrane transport protein....

Pathologic diagnosis of Mycobacterium infection from bony specimens was recorded for 35 (92%) patients. For 29 (76%), diagnosis was conducted by molecular study, including 25 (66%) by the national reference mycobacterial laboratory. For 4 patients, diagnosis was confirmed by culture of M. bovis. Osteomyelitis/osteitis for 5 patients was considered BCG related according to pathologic diagnosis o...

Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re) strain of Salmonella typhimurium was added to the BCG bacilli.

Introduction Mendelian susceptibility to mycobacterial disease (MSMD) is a rare form of primary immunodeficiencies characterized by predisposition for poorly virulent infection agents, primarily non-tuberculous mycobacteria and Salmonella. It has been shown that molecular basis of these diseases is mutations in at least 7 genes in the IL12-dependent IFN-g axis including IFNGR1, IFNGR2, IL-12/IL...

BCG (Calmette-Gu6rin bacillus) is presumed to protect against tuberculosis by virtue of the specific immune response it provokes in the vaccinated subject, but the measurement of this response is beset with technicM problems. First, the tubercle bacillus, against which specific resistance must ultimately be measured, is a poor indicator of the resistance generated in response to immunization. N...

salmonella is a gram-negative, non-spore forming facultative anaerobic, motile bacilli. in developing countries, non-typhoidal salmonella (nts) accounts for the steadily increase in the proportion of human infections in recent decades. the clinical presentations of non-typhoidal salmonella infection are protean, including gastroenteritis (the most common one), bacteremia, septic arthritis, oste...

Background and Objective: BCG vaccination is used in many countries with a high prevalence of TB to prevent childhood tuberculosis meningitis and miliary disease. Local and systemic sideeffects are associated with BCG vaccine. The most critical reaction is disseminated BCG infection which occurs in mostl...