Effective interruption of the Schistosoma life cycle is essential to blocking the parasite’s transmission, and thus truly preventing human schistosomiasis over the long term. Our current mass treatment campaigns were expected to limit transmission by reducing environmental contamination with parasite eggs. However, the process of transmission has proven to be very focal and highly efficient, su...

In view of the call by the World Health Organization (WHO) for elimination of schistosomiasis as a public health problem by 2025, use of molluscicides in snail control to supplement chemotherapy-based control efforts is likely to increase in the coming years. The mechanisms of action of niclosamide, the active ingredient in the most widely used molluscicides, remain largely unknown. A better un...