We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base pairs displays two widely different scenar...

The nucleotide sequence at the oriT region of the IncI1 plasmid R64 was determined. A recombinant plasmid carrying a 141-base-pair R64 sequence was mobilized with a normal frequency, while a plasmid carrying only 44 base pairs of this R64 sequence was mobilized with a frequency 1/10 that of the original plasmid. The oriT region of the R64 plasmid contains two inverted-repeat sequences.

Nucleosome positioning along the DNA sequence is often viewed as a combination of two distinct aspects – translational positioning and rotational positioning. With low-resolution ( 10–20 bases) mapping techniques such as MNase digestion of chromatin, only the approximate translational position of the nucleosomes is determined. Rotational positioning can be evaluated only when the outward/inward...