The intermolecular hydrogen bonding of barbiturates assists in the supramolecular aggregation and a hypsochromic shift is shown protic solvents.

A gas-chromatographic method is described for the quantitative deter. mination of 11 barbiturates and glutethimide in blood. The extracted barbiturates are methylated and injected into a 7% DC-200 column. Use of methohexital as the internal standard, as well as the addition of standards to a drug-free sample of blood, compensates for losses and for differences in the distribution coefficient of...

The effects of ten narcotic analgesics and three barbiturates have been investigated on respiratory rate, respiratory minute volume and blood Pco3 in the unanaesthetized rabbit. Both groups of drugs produced respiratory depression, and whilst the pattern of depression was similar for drugs of the same group, there were three main differences in the pattern of depression between the narcotic ana...