PURPOSE Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. METHODS In the present study, OCT-A based on a Heidelberg Engineering Spectralis system was used to investigate the vascular network in mic...

The ability of rats or mice to withstand the consequences of injury to myelinated axons in the CNS was previously shown to depend on the ability to manifest a T cell-mediated protective immune response, which is amenable to boosting by myelin-specific T cells. Here we show that this ability, assessed by retinal ganglion cell survival after optic nerve injury or locomotor activity after spinal c...

background: successful embryo transfer (et) technique is a fateful step of all efforts to achieve live births from in vitro produced embryos in assisted reproductive techniques or in knockout, transgenic or cloned animal projects. small reproductive tract of mice and limitation of current techniques may not well satisfy the requirements for mass production of genetically modified mice. genetic ...

background: to assess embryos derived by the transfer of meiosis-ii chromosomes (m-ii-t) from aged mice oocytes into ooplasms from younger mice to overcome the problem of age-related decline in female fertility. materials and methods: the developmental capacity karyotype and ultrastructure of reconstructed oocytes derived from meiosis-ii chromosome transplantation from aged mice into the ooplas...

background: in recent years, the widespread use of microwave producing instruments specially mobile phones; result in growing concern regarding the possible effects associated with these waves on human health. in the present study investigated the genotoxic effects of mobile phone radiation in adult mice (balb/c) and their embryos. methods: in this experimental research pregnant mice were irrad...

Citrullus colocynthis (CCT) is used in traditional medicine to inhibit the implantation of embryos. The objective of this study was to determine the number of embryos per pregnancy and the mortality rate in pregnant mice. 115 vaginal plug-positive mice were divided into 4 groups. The animals were given 30, 60 and 120 mg/kg hydroalcoholic extract of CCT until 17th day of gestation. Control group...

background: the present study has been carried out to investigate the effects of preovulatory stage gamma-irradiation of female mice in the absence or presence of vitamin e on numerical chromosome abnormalities in 8-cell embryos after mating with non-irradiated males. materials and methods: the 8-11 weeks adult female nmri mice were whole body irradiated at preovulatory stage (post pmsg injecti...

background: genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. germ cells especially spermatozoa are more vulnerable to suffering from dna damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. methods: to investigate the effec...

citrullus colocynthis (cct) is used in traditional medicine to inhibit the implantation of embryos. the objective of this study was to determine the number of embryos per pregnancy and the mortality rate in pregnant mice. 115 vaginal plug-positive mice were divided into 4 groups. the animals were given 30, 60 and 120 mg/kg hydroalcoholic extract of cct until 17th day of gestation. control group...

Background: It was reported in a literature that approximately one third of the 4-cell stage embryos did not exhibit a tetrahedral shape. Non-tetrahedral embryos showed a lower in vitro developmental potential than tetrahedral embryos. Recently vitrification technology has been widely employed for embryo cryopreservation. The objective of this study was to prove our hypothesis that vitrified - ...