Members of the Bacteroides fragilis group are among the most common anaerobic bacterial isolates in clinical specimens. Metronidazole, a 5-nitroimidazole, is often used as empirical therapy for anaerobic infections. Susceptibility testing is not routinely performed because of nearly universal susceptibility of Bacteroides spp. to this agent. We report a case of metronidazole-resistant Bacteroid...

A rapid multiplex PCR approach was developed to detect the bft gene subtypes in Bacteroides fragilis clinical isolates. This technique could be used to look at the epidemiology of enterotoxigenic strains of B. fragilis in clinical infections and whether there is a correlation between disease and the presence of B. fragilis enterotoxin.

1. Thompson JS, Malamy MH. Sequencing the gene for an imipenem-cefoxitin hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL 2480 reveals strong similarity between CfiA and Bacillus cereus b-lactamase II. J Bacteriol 1990; 172: 2584–93. 2. Edwards R, Read PN. Expression of the carbapenemase gene (cfiA) in Bacteroides fragilis. J Antimicrob Chemother 2000; 46: 1009–12. 3. Andrews JM. Determi...

conclusions: in the present study, we have figured out that a number of the important anaerobic infections treatment antibiotics have lost partly or totally their effectiveness on b. fragilis. background: bacteroides fragilis are among the most important anaerobic bacteria behind most of the anaerobic infections. they have acquired resistance to essential treatment antibiotics of anaerobic infe...

The Bacteroides fragilis NCTC 9343 genome is the fifth member of the Bacteroidetes/ Chlorobi group to be sequenced and the second Bacteroides fragilis strain. The Bacteroides fragilis NCTC 9343 genome shows considerable variation even within the same strain and ‘invertable promoters’ appear to regulate much of this variance in many surface-exposed and secreted proteins (Cerdeño-Tárraga et al., ...

Celiac disease (CD) is associated with intestinal dysbiosis, which can theoretically lead to dysfunctions in host-microbe interactions and contribute to the disease. In the present study, possible differences in Bacteroides spp. and their pathogenic features between CD patients and controls were investigated. Bacteroides clones (n = 274) were isolated, identified, and screened for the presence ...

The susceptibilities of recent clinical isolates of anaerobic bacteria from two community hospitals were determined. Thirty percent of pigmented Bacteroides species and bile-sensitive, nonpigmented Bacteroides species produced penicillinase and were resistant to amoxicillin. Cefoxitin and clindamycin showed good activity against most strains, with the exception of rare isolates of the Bacteroid...

BACKGROUND Periodic monitoring of antimicrobial resistance trends of clinically important anaerobic bacteria such as Bacteroides fragilis group organisms is required. We determined the antimicrobial susceptibilities of clinical isolates of B. fragilis group organisms recovered from 2009 to 2012 in a tertiary-care hospital in Korea. METHODS A total of 180 nonduplicate clinical isolates of B. f...

The activities of BMS-284576, clinafloxacin, moxifloxacin, sitafloxacin, trovafloxacin, imipenem, cefoxitin, and clindamycin against 589 Bacteroides fragilis group isolates were determined. The activity of BMS-284576 was comparable to that of trovafloxacin. Sitafloxacin and clinafloxacin were the most active quinolones, and moxifloxacin was the least active. B. fragilis was the most susceptible...

We identified enterotoxigenic Bacteroides fragilis in stool specimens of patients with inflammatory bowel disease and other gastrointestinal disorders. The organism was detected in 11 (13.2%) of 83 patients with inflammatory bowel disease. Of 57 patients with active disease, 19.3% were toxin positive; none of those with inactive disease had specimens positive for enterotoxigenic Bacteroides fra...