Hypothesis / aims of study Prior studies in a mouse model demonstrated that a new cell permeable peptide, R11, is bladder specific and can be retrieved in the bladder wall after intra-vesical instillation. This unique tissue specificity makes R11 a suitable candidate for intra-vesical antibiotic delivery for recurrent or relapsing bacterial cystitis. The rabbit bladder model is commonly used fo...

We describe severe necrohemorrhagic cystitis in a female rhesus macaque and a female cynomolgus macaque due to colonization of the urinary bladder by Corynebacterium sp. Clinically, both macaques presented with perineal bleeding and depression and, despite extensive and prolonged treatment, succumbed to the disease. At necropsy, the contents of the urinary bladders in both cases were hemorrhagi...

OBJECTIVES Hyaluronic acid is a protective barrier of the urothelium. A damaged glycosaminoglycan layer may increase the possibility of bacterial adherence and infection. This damage is proposed to be a causative factor in the development of interstitial cystitis, common urinary tract infections, and hemorrhagic cystitis due to posthematopoietic stem cell transplantation. The aim of this articl...

Introduction: Cystitis has high incidence in female population. Inflammation is responsible of irritative symptoms; it is supposed the existence of an arterial obstructive disease connected with bladder ischaemia. Direct bacterial damage and/or inflammation are responsible of the activation of ROS (radicals of oxygen) and consequent cell damage. NF-kB protein is protagonist in ROS synthesis. Hi...

Feline lower urinary tract diseases are known to be life threatening conditions in cats, especially when they occur as obstructive diseases in males. Early diagnosis and treatment is necessary, otherwise it may lead to death. A 3-year-old male Persian cat was referred to the clinic with a history of anuria, lethargy, loss of appetite and exploratory cystotomy 6 months ago due to urethral obstru...

Urinary tract infection, most frequently caused by Escherichia coli, is one of the most common bacterial infections in humans. A vast amount of literature regarding the mechanisms through which E. coli induces pyelonephritis has accumulated. Although cystitis accounts for 95% of visits to physicians for symptoms of urinary tract infections, few in vivo studies have investigated possible differe...

Histopathological examination of the urinary bladders of 63 patients dying in a geriatric clinic was performed. In 40 of 51 patients who had been treated with a urinary catheter, histological changes of polypoid cystitis were found. In 34 of the bladders the lesion engaged the posterior wall which corresponds to the localization of the tip of the catheter. The frequency of polypoid cystitis inc...

BACKGROUND A previous study revealed elevated serum Immunoglobulin E (IgE) in ketamine related cystitis (KC) patients. IgE might participate the pathogenesis of different types of bladder pain syndromes, including KC and interstitial cystitis (IC). OBJECTIVES To investigate the IgE expression in KC and IC bladder tissue. STUDY DESIGN Prospective evaluation. SETTING The study was conducted...

Background: Uncomplicated urinary tract infection (cystitis) is the most common bacterial among women visiting primary care clinics, and approximately 50% experience recurrence. Recurrent cystitis represents a substantial burden on patients’ quality of life, healthcare costs, antibiotics overuse.Current Concepts: Symptoms remain cornerstone diagnosis, urine culture necessary if recurrent suspec...