The transient receptor potential vanilloid type 1 (TRPV1) channel is one of the most well-characterized pain-inducing receptors. The purpose of this study was to predict human eye stinging of 19 baby bath and shampoo formulations by studying TRPV1 activity, as measured by increase in intracellular free Ca(2+). The NociOcular test, a novel recombinant neuronal in vitro model with high expression...

OBJECTIVE This study aimed to explore aspects of the effectiveness of three pressure-redistributing support surfaces in routine clinical practice. METHOD A non-randomised prospective cohort study was used, with skin outcomes reported for 219 subjects at risk of pressure ulcer development. RESULTS Few instances of new pressure damage were observed; these related to specific clinical issues, ...

EDRS Price MF-$0.65 HC=$3.29 Attention Span, *Bias; *Experimental Groups, *Infant Behavior, *Infants, R(Itsearch Methodology, *Research Problems This study investigated the common practice in infant research of eliminating from reported data large numbers of subjects who prove uncooperative (sleepy, fatigued, fussy) during the experiment. It was suggested that these excluded infants constitute ...

the physician role as a base. There might be perceived sexual gain or exploitation involved (about two-thirds of boundary cases have been such). But it might also involve perceived personal or ªnancial exploitation. (In the cases of boundary violations, we carefully use the word perceived because this is so often contended.) The second range of ethical misconduct is self-serving ªnancial gain o...

Every Thing Must Go is wildly ambitious. It advances substantive views on the proper scope of metaphysics (unifying science), the nature of reality (things subservient to structures), the current state of play in quantum gravity (fragmented), and the connection between fundamental physics and the rest of science (hard to summarise). It is both fascinating and infuriating. A key theme is the dis...