Yokonolide B (YkB; also known as A82548A), a spiroketal-macrolide, was isolated from Streptomyces diastatochromogenes B59 in a screen for inhibitors of beta-glucoronidase expression under the control of an auxin-responsive promoter in Arabidopsis. YkB inhibits the expression of auxin-inducible genes as shown using native and synthetic auxin promoters as well as using expression profiling of 830...

ated aging. J Gerontol Biol Sci 49:B245. Klinger MM, MacCarter GD, Boozer CN. 1996. Body weight and composition in the Sprague Dawley rat: Comparison of three outbred sources. Lab Anim Sci 46:67-70. Lipman RD, Chrisp CE, Hazzard DG, Branson RT. 1996. Pathologic characterization of Brown Norway, Brown Norway X Fischer 344, and Fischer 344 X Brown Norway rats with relation to age. J Gerontol Biol...

ated aging. J Gerontol Biol Sci 49:B245. Klinger MM, MacCarter GD, Boozer CN. 1996. Body weight and composition in the Sprague Dawley rat: Comparison of three outbred sources. Lab Anim Sci 46:67-70. Lipman RD, Chrisp CE, Hazzard DG, Branson RT. 1996. Pathologic characterization of Brown Norway, Brown Norway X Fischer 344, and Fischer 344 X Brown Norway rats with relation to age. J Gerontol Biol...

through the advent of heterodox approaches in modern economic methodology, mccloskey's contribution on introducing rhetoric in methodology has been nominated as one of the most controversial propositions ever alleged in the literature. concerning new predominant perspectives in philosophy of language, this paper seeks to analyze the theoretical status of rhetoric in the methodology of econ...

The role of T lymphocytes in the control of chronic myeloid leukemia (CML) after bone marrow transplantations has been clearly shown. This effect closely correlates with graft-versus-host disease (GVHD). A specific graft-versus-leukemia (GVL) effect separate from GVHD has been postulated but has been difficult to show. One possible target for specific GVL activity is the bcr-abl fusion protein ...

We combined sensitive near-infrared data obtained with ground-based imagers on the ESO NTT and VLT telescopes with space mid-infrared data acquired with the IRAC imager on the Spitzer Space Telescope to calculate the extinction law Aλ/AKS as a function of λ between 1.25 and 7.76 μm to an unprecedented depth in Barnard 59, a star forming, dense core located in the Pipe Nebula. The ratios Aλ/AKS ...

Objective: Bladder cancer can be imaged as a sustaining multistage course accumulating genetic and epigenetic changes. Moreover, plenty of studies uncovered that A-to-I RNA editing is an essential part of the growth of normal cells and involved in the variety of biological pathways. To better understand bladder cancer pathogenesis at the molecular level and to uncover novel tumor-initiating eve...

The Pipe Nebula is a massive, nearby dark molecular cloud with a low star-formation efficiency which makes it a good laboratory to study the very early stages of the star formation process. The Pipe Nebula is largely filamentary, and appears to be threaded by a uniform magnetic field at scales of few parsecs, perpendicular to its main axis. The field is only locally perturbed in a few regions, ...

RATIONALE Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients. In addition, technological advances in solid-phase assays have permitted more comprehensive assessment of donor-specific antibodies. Although various desen...