نتایج جستجو برای: b23 واژگان کلیدی رفتار مصرفی
تعداد نتایج: 106122 فیلتر نتایج به سال:
Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a c...
U1 bladder cancer cells of high malignancy exhibited higher proliferation capacity than U4 premalignant cells. Higher expression of Ras, c-Myc, and nucleophosmin/B23 and greater c-Myc transactivation and nucleophosmin/B23 promoter activities were detected in U1 cells compared with U4 cells. Moreover, c-Myc and nucleophosmin/B23 were increased in U1 but not in U4 cells upon serum stimulation fro...
PES1, the human homolog of zebrafish pescadillo, is a nucleolar protein that is essential for cell proliferation. We report herein that a nucleolar marker protein B23 physically interacts with PES1 and is involved in the nucleolar localization of PES1. In vivo interaction between B23 and PES1 was verified by co-immunoprecipitation of endogenous B23 and PES1 proteins, and they showed cellular co...
چکیده زمینه و هدف: سل یک بیماری عفونی است که در اثر مجموعه ی مایکوباکتریوم های سلی ایجاد می گردد. این بیماری یکی از شایع ترین بیماری های عفونی بوده که منجر به بیش از 2 میلیون مرگ سالانه در جهان می گردد. هدف از انجام این بررسی تعیین تاثیر بسته ی طراحی شده ی آموزش بهداشت بر رفتارهای بهداشتی مسلولین مراجعه کننده به انستیتو پاستور بوده است . روش بررسی: پژوهش حاضر یک مطالعه ی نیمه تجربی بود که بر رو...
We report the characterization of a nucleolar localization sequence (NoLS) that targets the green fluorescent protein (GFP) into the granular component (GC) of nucleoli. This NoLS interacts in vitro specifically and directly with the major nucleolar protein B23 and more precisely with the region of B23 including the two acidic stretches. The affinity of NoLS for B23 is stronger than that of the...
Ubiquitin-like protein/sentrin-specific proteases (Ulp/SENPs) mediate both processing and deconjugation of small ubiquitin-like modifier proteins (SUMOs). Here, we show that Ulp/SENP family members SENP3 and SENP5 localize within the granular component of the nucleolus, a subnucleolar compartment that contains B23/nucleophosmin. B23/nucleophosmin is an abundant shuttling phosphoprotein, which p...
چکیده زمینه وهدف: مطالعات دهه های اخیر، بر نقش رفتار های ناایمن، به عنوان عامل اصلی حوادث، تاکید دارند. استفاده از تابلوهای ایمنی، روش تکمیلی برای کنترل حوادث و رفتارهای ناایمن به حساب می آید. لذا هدف از این مطالعه ارزیابی تأثیر کاربرد تابلو های ایمنی بر اصلاح رفتارهای ناایمن بود. روش بررسی: مطالعه مداخله ای حاضر، در یکی از صنایع ساخت توربین انجام شد. در این مطالعه از روش نمونه برداری از رفتار ...
The association of a specific autoantibody response with distinct disease phenotypes is observed in both autoimmune diseases and cancer. Although the underlying mechanisms remain unclear, it is likely that unique properties of disease-specific autoantigens expressed in the relevant target cells play a role. It has recently been observed that the majority of autoantigens targeted across the spec...
Nucleophosmin (NPM1/B23) is a nucleolar protein implicated in growth-associated functions, in which the RNA binding activity of B23 plays essential roles in ribosome biogenesis. The C-terminal globular domain (CTD) of B23 has been believed to be the RNA binding domain because the splicing variant B23.2 lacking the CTD binds considerably less efficiently to RNA. However, the recognition of targe...
Nuclear bodies are membraneless organelles that play important roles in genome functioning. A specific type of nuclear bodies known as interphase prenucleolar bodies (iPNBs) are formed in the nucleoplasm after hypotonic stress from partially disassembled nucleoli. iPNBs are then disassembled, and the nucleoli are reformed simultaneously. Here, we show that diffusion of B23 molecules (also known...
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