The aim of this work was to compare hepatocellular toxicity and pharmacological activity of amiodarone (2-n-butyl-3-[3,5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran; B2-O-Et-N-diethyl) and of eight amiodarone derivatives. Three amiodarone metabolites were studied, namely, mono-N-desethylamiodarone (B2-O-Et-NH-ethyl), di-N-desethylamiodarone (B2-O-Et-NH(2)), and (2-butyl-benzofuran-3-yl)-(4-h...

(54) GENERATING PROSODIC CONTOURS FOR 6,871,178 B2 3/2005 Case et al. SYNTHESIZED SPEECH 6,975,987 B1 12/2005 Tenpaku et a1. 6,990,449 B2 1/2006 Case . 6,990,450 B2 l/2006 Case et al. (75) Inventors: Martin Jansclhe, New York, NY (US); 7,035,791 B2 400% Chazan et a1‘ Mlchael DRlley, New York, NY (Us); 7,062,439 B2 6/2006 Brittan et al. Andrew M. Rosenberg, Brooklyn, NY 7,076,426 B1 7/2006 Beutn...

Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective neuronal migration. The similarities in amino acid sequences, expression patterns, and knockout phenotypes raise the question of whether the two ...

Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo. In the present study, we evaluated the antiproliferative activity of DRS-B2 on numerous tumor cell lines, its cell internalization and studies of its molecular partners as ...

Objective: To evaluate avidity of IgG anti-b2-glycoprotein I antibodies (anti-b2-GPI) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in relation to thrombosis, and to demonstrate a possible affinity maturation of IgG anti-b2-GPI during the disease course. Methods: 64 sera from 32 patients (18 with primary or secondary APS, 14 with SLE without APS) and th...

6,324,532 B1* 11/2001 Spence et a1. ................. .. 706/27 6,901,167 B2 5/2005 Herley 7,286,707 B2 10/2007 Liu et a1. 7,702,596 B2 4/2010 Tu et a1. 7,848,566 B2 * 12/2010 Schneiderman ............ .. 382/159 8,092,388 B2 * 1/2012 Park et a1. ................... .. 600/45

Recent studies on the constituent binaries of common NiTi-based shape memory alloys (NiTi, NiZr, NiHf, PdTi, PtTi) have led to questions regarding accuracy current phase diagrams, including existence theoretical phases, and atomistic nature stability in observed martensitic austenitic phases. These issues are investigated here with ab initio molecular dynamics. Theoretically identified ground s...

The oxidation-reduction properties of free cytochrome b2 isolated by controlled proteolysis from flavocytochrome b2, i.e. the flavodehydrogenase-bound cytochrome b2, were investigated by using stopped-flow spectrophotometry. The rapid kinetics of the reduction of cytochrome b2 by flavocytochrome b2 in the presence of L-lactate are reported. The self-exchange rate constant between reduced cytoch...

Regulation of the constitutively expressed type 2 bradykinin (B2) receptor, which mediates the principal actions of bradykinin, occurs at multiple levels. The goal of the current study was to determine whether the human B2 3'-untranslated region (UTR) has effects on gene expression, with particular focus on the variable number of tandem repeats (B2-VNTR) polymorphic portion of the 3'-UTR and it...

The vascular endothelium is a crucial interface that controls the recruitment of circulating leukocytes. Based on the luminal expression of the ephrin-B2 ligand by endothelial cells (ECs) and the expression of EphB receptors (EphBRs) by circulating monocytes, we hypothesized that EphBR-ephrinB interactions are involved in monocyte adhesion. Adhesion experiments with monocytic cells were perform...