نتایج جستجو برای: azoles

تعداد نتایج: 1992  

Journal: :The Journal of antimicrobial chemotherapy 1996
S Hawser M Francolini K Islam

The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experime...

Journal: :Organic & biomolecular chemistry 2015
Xuebing Chen Youzhi Wu Jinyi Xu Hequan Yao Aijun Lin Yue Huang

A Rh(iii)-catalyzed cyclization of azoles with alkynes has been developed. A variety of azole-fused-pyridines were obtained in good to excellent yields and regioselectivity. Both the C5 and the C4 position of azoles were suitable for the reaction.

Journal: :Antimicrobial agents and chemotherapy 2003
Chiatogu Onyewu Jill R Blankenship Maurizio Del Poeta Joseph Heitman

Azoles target the ergosterol biosynthetic enzyme lanosterol 14alpha-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity, and low toxicity. Unfortunately, azoles are generally fungistatic and resistance to fluconazole is emerging in several fungal pathogens. We recently established that the protein phosphatase calci...

2017
F Katiraee S Ahmadi Afshar SF Rahimi Pirmahalleh H Shokri

Background and Purpose Candidaalbicans is the most common cause of candidal infections. Various studies have shown drug resistance among C. albicans isolates; thus, it is necessary to discover replacement treatments for Candida infections. In this study, we aimed to compare the effects of different essential oils against azoles-resistant and azoles-susceptible isolates. Materials and Methods ...

Journal: Current Medical Mycology 2017

Backgrounds and aims: Candida albicans is more prevalent between Candida species which can cause candidal infection. Various studies have shown drug resistance among the C. albicans isolates, so it is now necessary to discover replacement treatments for the Candida infection. The aim of this study is comparison the effects of different Essential oils (EOs) against azoles-resistant and azoles-su...

Journal: :Revista Iberoamericana de Micología 2007

Journal: :Chemical communications 2015
Arkaitz Correa Béla Fiser Enrique Gómez-Bengoa

The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo)azoles constituting straightforward access to heterocycles of utmost medicinal significance and highlighting the convenient use of feedstoc...

Journal: :Current opinion in investigational drugs 2010
Alessandro C Pasqualotto Karoline O Thiele Luciano Z Goldani

Azoles are important compounds for the treatment of fungal infections. This review focuses on three azoles: isavuconazole, ravuconazole and albaconazole (Stiefel). These drugs exhibit a broad spectrum of activity in vitro, including activity against several fungal isolates that are resistant to other azoles. However, poor or limited activity of these compounds has been demonstrated against spec...

Journal: :The Journal of antimicrobial chemotherapy 2009
Lan Yan Miaohai Li Yongbing Cao Pinghui Gao Yingying Cao Yan Wang Yuanying Jiang

OBJECTIVES To evaluate the effect of Candida albicans mitochondrial respiratory status on antifungal azole susceptibility. METHODS The inhibitors cyanide and salicylhydroxamic acid (SHAM) were each combined with azoles to examine the effect of the combinations on C. albicans. C. albicans strains deleted for the alternative oxidase (Aox) were also examined for susceptibility to azoles and for ...

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