Previous studies from this group have shown that limit size lipid-based systems – defined as the smallest achievable aggregates compatible with the packing properties of their molecular constituents – can be efficiently produced using rapid microfluidic mixing technique. In this work, it is shown that similar procedures can be employed for the production of homogeneously sized unilamellar vesic...

Great strides were made during the last century in the management of diabetes in pregnancy. Before the discovery of insulin in 1921 the outlook for the diabetic mother and her fetus was abysmal. With the advent of insulin, an emphasis on a team approach to care, improved methods of fetal surveillance, and a focus on metabolic normalisation brought about by intensive insulin regimens and home gl...

N-Methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]benzamide (axitinib) is an oral inhibitor of vascular endothelial growth factor receptors 1–3, which is approved for the treatment of advanced renal cell cancer. Human [C]-labeled clinical studies indicate axitinib’s primary route of clearance is metabolism. The aims of the in vitro experiments presented herein were to identify an...

Günümüzde geliþen teknolojinin bize sunduðu pozitron emisyon tomografi (PET), magnetoensefalografi, tek foton emisyon komputerize tomografi (SPECT), bilgisayarlý beyin tomografisi, manyetik rezonans gibi görüntüleme yöntemleri ile birlikte elektroensefalografi (EEG) (uyarýlmýþ potansiyeller ve olaya iliþkin potansiyeller de dahil olmak üzere) sadece araþtýrma amaçlý deðil doðrudan klinik uygula...

This paper provides procedures for constructing unbiased simultaneous prediction limits on the observations or functions of observations of all of k future samples using the results of a previous sample from the same underlying distribution belonging to invariant family. The results have direct application in reliability theory, where the time until the first failure in a group of several items...

According to higher-order thought accounts of phenomenal consciousness it is unlikely that many non-human animals undergo phenomenally conscious experiences. Many people believe that this result would have deep and far-reaching consequences. More specifically, they believe that the absence of phenomenal consciousness from the rest of the animal kingdom must mark a radical and theoretically sign...

Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is how this neuronal representation of value depends on the behavioral context. He...

Most models used in climate economics so far are full-employment models. In Germany, as in other countries suffering from persistent unemployment, climate policy can only be successful if it is embedded in an economic policy that generates additional jobs at a large scale. To investigate the possibility for such embedding, a long-term model of the German economy is needed. lagom sim is such a m...