Hydrology and Water Resources, University of Arizona, Tucson, AZ 85721, USA b School of Natural Resources and the Environment, University of Arizona, Tucson, AZ 85721, USA Biosphere 2 Earthscience, University of Arizona, Tucson, AZ 85721, USA d Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA Merriam Powell Center for Environmental Research, Northern Arizona Univer...

Electron transfer (ET) proteins are biomolecules with specific functions, selected by evolution. As such they are attractive candidates for use in potential bioelectronic devices. The blue copper protein azurin (Az) is one of the most-studied ET proteins. Traditional spectroscopic, electrochemical, and kinetic methods employed for studying ET to/from the protein's Cu ion have been complemented ...

Meningitis: An Institutional Review Ana Moran, MD; Wyatt Ramey; Brian Beck MD; Yashar Kalani, MD, PhD; Andrew Montoure; Kris Smith; Nicholas Theodore, MD; Peter Nakaji, MD; Omar Gonzalez, MD; Infectious Diseases, Barrow Neurological Institute, Phoenix, AZ; Barrow Neurological Institute, Phoneix, AZ; Neurology, Barrow Neurological Institute, Phoenix, AZ; Neurosurgery, Barrow Neurological Institu...

1 Department of Applied Mathematics, Arizona State University, Tempe, AZ 2 Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 3 School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 4 Department of Physics, National University of Salta, Salta, Argentina 5 School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 6 ...

To directly evaluate the role of increased ornithine decarboxylase (ODC) and polyamines in mouse skin carcinogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to direct the expression of antizyme (AZ) to specific skin cell populations. AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyam...

Ornithine decarboxylase (ODC) is a ubiquitous enzyme that is conserved in all species from bacteria to humans. Mammalian ODC is degraded by the proteasome in a ubiquitin-independent manner by direct binding to the antizyme (AZ). In contrast, Trypanosoma brucei ODC has a low binding affinity toward AZ. In this study, we identified key amino acid residues that govern the differential AZ binding a...

To directly evaluate the role of increased ornithine decarboxylase (ODC) and polyamines in mouse skin carcinogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to direct the expression of antizyme (AZ) to specific skin cell populations. AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyam...

The oil palm (Elaeis guineensis Jacq.) fruit primary abscission zone (AZ) is a multi-cell layered boundary region between the pedicel (P) and mesocarp (M) tissues. To examine the cellular processes that occur during the development and function of the AZ cell layers, we employed multiple histological and immunohistochemical methods combined with confocal, electron and Fourier-transform infrared...