lithium is a drug used for the treatment of bipolar disorder. it has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-ht1b/1d serotonin receptors. sumatriptan is a 5-ht1b/1d receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. in this study, effects of lithium on sumatrip...

introduction: neurohormones like testosterone and estradiol have an important role in learning and memory. the hippocampus is essentially involved in learning and memory, and is known to be a target for estradiol actions. estrogen receptors (ers) are highly expressed in ca1 of rat hippocampus, and mediate the effects of estrogen on learning and memory. estradiol receptor belong to a family of t...

alzheimer’s disease (ad) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. pelargonidin (pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. this study was designed to assess pel memory enhancing effects on the a rat amyloid beta 25-35 (aβ) intrahippocampal microinjections model of ad in...

Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer’s disease (AD). This research aimed to investigate ...

electromagnetic field (emf) radiation affects cellular and brain chemistry and function, resulting in deleterious effects such as free radicals formation, impaired dna repair, reduced melatonin and blood brain barrier protection, and defects on learning and memory and other higher brain functions. in this paper the effects of low frequency emf of 50- and 217 hz, ranges often associated with com...

objective: diabetes is a metabolic disorder which impairs carbohydrate and lipid metabolism. it is accompanied by cognition impairment in diabetic patients and animal models. lipids play an important role in nerve membrane composition, structure and function. this study was designed to evaluate the effect of dietary butter and sesame oils on passive avoidance memory of streptozotocin (stz) diab...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

There is strong evidence that two cerebral hemispheres are differentially involved in emotional memory and that amygdala is a key subcortical structure for emotional experience. The present research investigated the possible involvement of lateralization of basolateral amygdala (BLA) and central amygdala (CEA) in place avoidance memory. For this purpose, male Long-Evans rats (280-320 g) were im...

introduction: lead (pb) is a neurotoxin that its different effects on the central nervous system are well-known. previous studies have reported the potent effects of vitamin c on memory.the present study was undertaken to evaluate the protective effects of vitamin c against leadinduced amnesia. methods: male wistar rats were divided into 4 groups: the control (saline), negative control (lead), ...